Lifespan extension by methionine restriction requires autophagy-dependent vacuolar acidification.

Lifespan extension by methionine restriction requires autophagy-dependent vacuolar acidification.

Reduced supply of the amino acid methionine increases longevity across species through an as yet elusive mechanism. Here, we report that methionine restriction (MetR) extends yeast chronological lifespan in an autophagy-dependent manner. Single deletion of several genes essential for autophagy (ATG5...

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Bibliographic Details
Main Authors: Christoph Ruckenstuhl, Christine Netzberger, Iryna Entfellner, Didac Carmona-Gutierrez, Thomas Kickenweiz, Slaven Stekovic, Christina Gleixner, Christian Schmid, Lisa Klug, Alice G Sorgo, Tobias Eisenberg, Sabrina Büttner, Guillermo Mariño, Rafal Koziel, Pidder Jansen-Dürr, Kai-Uwe Fröhlich, Guido Kroemer, Frank Madeo
Format: article
Language:EN
Published: Public Library of Science (PLoS) 2014
Subjects:
Genetics
QH426-470
Online Access:https://doaj.org/article/2513812671d248ae85a0d77c88148d65
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Internet

https://doaj.org/article/2513812671d248ae85a0d77c88148d65

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