NOTCH-ing up nucleotide metabolism in T-cell acute lymphoblastic leukemia

In a recent issue of Science Advances, Srivastava et al. report a novel nucleotide biosynthesis regulatory role for UBR7 in NOTCH1-driven T-ALL. Here we will discuss their key findings and the implications for using cancer metabolism to understand the development and progression of T-ALL.

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Detalles Bibliográficos
Autor principal:	Andrew Volk
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/251f1a27ee844af19641e05ddcf19a98
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spelling	oai:doaj.org-article:251f1a27ee844af19641e05ddcf19a982021-12-02T18:18:50ZNOTCH-ing up nucleotide metabolism in T-cell acute lymphoblastic leukemia10.1038/s42003-021-02330-82399-3642https://doaj.org/article/251f1a27ee844af19641e05ddcf19a982021-06-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02330-8https://doaj.org/toc/2399-3642In a recent issue of Science Advances, Srivastava et al. report a novel nucleotide biosynthesis regulatory role for UBR7 in NOTCH1-driven T-ALL. Here we will discuss their key findings and the implications for using cancer metabolism to understand the development and progression of T-ALL.Andrew VolkNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-3 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Andrew Volk NOTCH-ing up nucleotide metabolism in T-cell acute lymphoblastic leukemia
description	In a recent issue of Science Advances, Srivastava et al. report a novel nucleotide biosynthesis regulatory role for UBR7 in NOTCH1-driven T-ALL. Here we will discuss their key findings and the implications for using cancer metabolism to understand the development and progression of T-ALL.
format	article
author	Andrew Volk
author_facet	Andrew Volk
author_sort	Andrew Volk
title	NOTCH-ing up nucleotide metabolism in T-cell acute lymphoblastic leukemia
title_short	NOTCH-ing up nucleotide metabolism in T-cell acute lymphoblastic leukemia
title_full	NOTCH-ing up nucleotide metabolism in T-cell acute lymphoblastic leukemia
title_fullStr	NOTCH-ing up nucleotide metabolism in T-cell acute lymphoblastic leukemia
title_full_unstemmed	NOTCH-ing up nucleotide metabolism in T-cell acute lymphoblastic leukemia
title_sort	notch-ing up nucleotide metabolism in t-cell acute lymphoblastic leukemia
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/251f1a27ee844af19641e05ddcf19a98
work_keys_str_mv	AT andrewvolk notchingupnucleotidemetabolismintcellacutelymphoblasticleukemia
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NOTCH-ing up nucleotide metabolism in T-cell acute lymphoblastic leukemia

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