Children and adolescents with neurodevelopmental disorders show cognitive heterogeneity and require a person-centered approach

Abstract We aimed to identify patterns of cognitive differences and characterize subgroups of Mexican children and adolescents with three neurodevelopmental disorders (NDD): intellectual disability (ID), autism spectrum disorders (ASD) and attention deficit/hyperactivity disorder (ADHD). The sample...

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Autores principales:	María Elena Márquez-Caraveo, Rocío Rodríguez-Valentín, Verónica Pérez-Barrón, Ruth Argelia Vázquez-Salas, José Carlos Sánchez-Ferrer, Filipa De Castro, Betania Allen-Leigh, Eduardo Lazcano-Ponce
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/25482762499c4d52b9b920f1ddc8b930
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spelling	oai:doaj.org-article:25482762499c4d52b9b920f1ddc8b9302021-12-02T18:02:06ZChildren and adolescents with neurodevelopmental disorders show cognitive heterogeneity and require a person-centered approach10.1038/s41598-021-97551-62045-2322https://doaj.org/article/25482762499c4d52b9b920f1ddc8b9302021-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-97551-6https://doaj.org/toc/2045-2322Abstract We aimed to identify patterns of cognitive differences and characterize subgroups of Mexican children and adolescents with three neurodevelopmental disorders (NDD): intellectual disability (ID), autism spectrum disorders (ASD) and attention deficit/hyperactivity disorder (ADHD). The sample included 74 children and adolescents 6–15 years; 34% had ID, ASD or ADHD, 47% had ID in comorbidity with ASD, ADHD or both, 11% had ASD + ADHD, 8% were children without NDD. We applied WISC-IV, Autism Diagnostic Interview-Revised, Mini-International Neuropsychiatric Structured Interview, Child Behavior Checklist, and UNICEF Child Functioning Module. We evaluated the normality of the WISC-IV sub-scales using the Shapiro-Francia test, then conducted a latent class analysis and assessed inter-class differences in terms of household, parent and child characteristics. The following four-class solution best fit the data: “Lower Cognitive Profile” (LCP), “Lower Working Memory” (LWM), “Higher Working Memory” (HWM), “Higher Cognitive Profile” (HCP). LCP included most of the children with ID, who had a low Working Memory (WM) index score. LWM included mainly children with ASD or ID + ADHD; their Perceptual Reasoning (PR) and Processing Speed (PS) index scores were much higher than those for Verbal Comprehension (VC) and WM. HWM included children with ASD or ADHD; their scores for PR, PS and VC were high with lower WM (although higher than for LWM). HCP included children without NDD and with ASD or ADHD or both and had the highest scores on all indices. Children with NDD show cognitive heterogeneity and thus require individualized treatment plans.María Elena Márquez-CaraveoRocío Rodríguez-ValentínVerónica Pérez-BarrónRuth Argelia Vázquez-SalasJosé Carlos Sánchez-FerrerFilipa De CastroBetania Allen-LeighEduardo Lazcano-PonceNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q María Elena Márquez-Caraveo Rocío Rodríguez-Valentín Verónica Pérez-Barrón Ruth Argelia Vázquez-Salas José Carlos Sánchez-Ferrer Filipa De Castro Betania Allen-Leigh Eduardo Lazcano-Ponce Children and adolescents with neurodevelopmental disorders show cognitive heterogeneity and require a person-centered approach
description	Abstract We aimed to identify patterns of cognitive differences and characterize subgroups of Mexican children and adolescents with three neurodevelopmental disorders (NDD): intellectual disability (ID), autism spectrum disorders (ASD) and attention deficit/hyperactivity disorder (ADHD). The sample included 74 children and adolescents 6–15 years; 34% had ID, ASD or ADHD, 47% had ID in comorbidity with ASD, ADHD or both, 11% had ASD + ADHD, 8% were children without NDD. We applied WISC-IV, Autism Diagnostic Interview-Revised, Mini-International Neuropsychiatric Structured Interview, Child Behavior Checklist, and UNICEF Child Functioning Module. We evaluated the normality of the WISC-IV sub-scales using the Shapiro-Francia test, then conducted a latent class analysis and assessed inter-class differences in terms of household, parent and child characteristics. The following four-class solution best fit the data: “Lower Cognitive Profile” (LCP), “Lower Working Memory” (LWM), “Higher Working Memory” (HWM), “Higher Cognitive Profile” (HCP). LCP included most of the children with ID, who had a low Working Memory (WM) index score. LWM included mainly children with ASD or ID + ADHD; their Perceptual Reasoning (PR) and Processing Speed (PS) index scores were much higher than those for Verbal Comprehension (VC) and WM. HWM included children with ASD or ADHD; their scores for PR, PS and VC were high with lower WM (although higher than for LWM). HCP included children without NDD and with ASD or ADHD or both and had the highest scores on all indices. Children with NDD show cognitive heterogeneity and thus require individualized treatment plans.
format	article
author	María Elena Márquez-Caraveo Rocío Rodríguez-Valentín Verónica Pérez-Barrón Ruth Argelia Vázquez-Salas José Carlos Sánchez-Ferrer Filipa De Castro Betania Allen-Leigh Eduardo Lazcano-Ponce
author_facet	María Elena Márquez-Caraveo Rocío Rodríguez-Valentín Verónica Pérez-Barrón Ruth Argelia Vázquez-Salas José Carlos Sánchez-Ferrer Filipa De Castro Betania Allen-Leigh Eduardo Lazcano-Ponce
author_sort	María Elena Márquez-Caraveo
title	Children and adolescents with neurodevelopmental disorders show cognitive heterogeneity and require a person-centered approach
title_short	Children and adolescents with neurodevelopmental disorders show cognitive heterogeneity and require a person-centered approach
title_full	Children and adolescents with neurodevelopmental disorders show cognitive heterogeneity and require a person-centered approach
title_fullStr	Children and adolescents with neurodevelopmental disorders show cognitive heterogeneity and require a person-centered approach
title_full_unstemmed	Children and adolescents with neurodevelopmental disorders show cognitive heterogeneity and require a person-centered approach
title_sort	children and adolescents with neurodevelopmental disorders show cognitive heterogeneity and require a person-centered approach
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/25482762499c4d52b9b920f1ddc8b930
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Children and adolescents with neurodevelopmental disorders show cognitive heterogeneity and require a person-centered approach

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