A neural basis for brain leptin action on reducing type 1 diabetic hyperglycemia

Leptin can rescue hyperglycemia in type 1 diabetes, but the underlying mechanisms for this effect are not clear. Here, the authors report that leptin action is mediated by inhibition of the heightened activity of arcuate GABA neurons in murine models of type 1 diabetes through restoring nutrient sen...

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Autores principales: Shengjie Fan, Yuanzhong Xu, Yungang Lu, Zhiying Jiang, Hongli Li, Jessie C. Morrill, Jing Cai, Qi Wu, Yong Xu, Mingshan Xue, Benjamin R. Arenkiel, Cheng Huang, Qingchun Tong
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/255498daebe9486b8e6c221df124dd75
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