A neural basis for brain leptin action on reducing type 1 diabetic hyperglycemia

Leptin can rescue hyperglycemia in type 1 diabetes, but the underlying mechanisms for this effect are not clear. Here, the authors report that leptin action is mediated by inhibition of the heightened activity of arcuate GABA neurons in murine models of type 1 diabetes through restoring nutrient sen...

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Autores principales:	Shengjie Fan, Yuanzhong Xu, Yungang Lu, Zhiying Jiang, Hongli Li, Jessie C. Morrill, Jing Cai, Qi Wu, Yong Xu, Mingshan Xue, Benjamin R. Arenkiel, Cheng Huang, Qingchun Tong
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/255498daebe9486b8e6c221df124dd75
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spelling	oai:doaj.org-article:255498daebe9486b8e6c221df124dd752021-12-02T16:58:08ZA neural basis for brain leptin action on reducing type 1 diabetic hyperglycemia10.1038/s41467-021-22940-42041-1723https://doaj.org/article/255498daebe9486b8e6c221df124dd752021-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22940-4https://doaj.org/toc/2041-1723Leptin can rescue hyperglycemia in type 1 diabetes, but the underlying mechanisms for this effect are not clear. Here, the authors report that leptin action is mediated by inhibition of the heightened activity of arcuate GABA neurons in murine models of type 1 diabetes through restoring nutrient sensing.Shengjie FanYuanzhong XuYungang LuZhiying JiangHongli LiJessie C. MorrillJing CaiQi WuYong XuMingshan XueBenjamin R. ArenkielCheng HuangQingchun TongNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Shengjie Fan Yuanzhong Xu Yungang Lu Zhiying Jiang Hongli Li Jessie C. Morrill Jing Cai Qi Wu Yong Xu Mingshan Xue Benjamin R. Arenkiel Cheng Huang Qingchun Tong A neural basis for brain leptin action on reducing type 1 diabetic hyperglycemia
description	Leptin can rescue hyperglycemia in type 1 diabetes, but the underlying mechanisms for this effect are not clear. Here, the authors report that leptin action is mediated by inhibition of the heightened activity of arcuate GABA neurons in murine models of type 1 diabetes through restoring nutrient sensing.
format	article
author	Shengjie Fan Yuanzhong Xu Yungang Lu Zhiying Jiang Hongli Li Jessie C. Morrill Jing Cai Qi Wu Yong Xu Mingshan Xue Benjamin R. Arenkiel Cheng Huang Qingchun Tong
author_facet	Shengjie Fan Yuanzhong Xu Yungang Lu Zhiying Jiang Hongli Li Jessie C. Morrill Jing Cai Qi Wu Yong Xu Mingshan Xue Benjamin R. Arenkiel Cheng Huang Qingchun Tong
author_sort	Shengjie Fan
title	A neural basis for brain leptin action on reducing type 1 diabetic hyperglycemia
title_short	A neural basis for brain leptin action on reducing type 1 diabetic hyperglycemia
title_full	A neural basis for brain leptin action on reducing type 1 diabetic hyperglycemia
title_fullStr	A neural basis for brain leptin action on reducing type 1 diabetic hyperglycemia
title_full_unstemmed	A neural basis for brain leptin action on reducing type 1 diabetic hyperglycemia
title_sort	neural basis for brain leptin action on reducing type 1 diabetic hyperglycemia
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/255498daebe9486b8e6c221df124dd75
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A neural basis for brain leptin action on reducing type 1 diabetic hyperglycemia

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