A neural basis for brain leptin action on reducing type 1 diabetic hyperglycemia
Leptin can rescue hyperglycemia in type 1 diabetes, but the underlying mechanisms for this effect are not clear. Here, the authors report that leptin action is mediated by inhibition of the heightened activity of arcuate GABA neurons in murine models of type 1 diabetes through restoring nutrient sen...
Guardado en:
Autores principales: | Shengjie Fan, Yuanzhong Xu, Yungang Lu, Zhiying Jiang, Hongli Li, Jessie C. Morrill, Jing Cai, Qi Wu, Yong Xu, Mingshan Xue, Benjamin R. Arenkiel, Cheng Huang, Qingchun Tong |
---|---|
Formato: | article |
Lenguaje: | EN |
Publicado: |
Nature Portfolio
2021
|
Materias: | |
Acceso en línea: | https://doaj.org/article/255498daebe9486b8e6c221df124dd75 |
Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
Ejemplares similares
-
A neural basis for antagonistic control of feeding and compulsive behaviors
por: Leandra R. Mangieri, et al.
Publicado: (2018) -
Identification of a neurocircuit underlying regulation of feeding by stress-related emotional responses
por: Yuanzhong Xu, et al.
Publicado: (2019) -
Paraventricular hypothalamus mediates diurnal rhythm of metabolism
por: Eun Ran Kim, et al.
Publicado: (2020) -
Hypothalamic leptin action is mediated by histone deacetylase 5
por: Dhiraj G. Kabra, et al.
Publicado: (2016) -
Autophagy in muscle of glucose-infusion hyperglycemia rats and streptozotocin-induced hyperglycemia rats via selective activation of m-TOR or FoxO3.
por: Pengfei Lv, et al.
Publicado: (2014)