MR imaging for the quantitative assessment of brain iron in aceruloplasminemia: A postmortem validation study

MR imaging for the quantitative assessment of brain iron in aceruloplasminemia: A postmortem validation study

Aims: Non-invasive measures of brain iron content would be of great benefit in neurodegeneration with brain iron accumulation (NBIA) to serve as a biomarker for disease progression and evaluation of iron chelation therapy. Although magnetic resonance imaging (MRI) provides several quantitative measu...

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Main Authors: Lena H.P. Vroegindeweij, Piotr A. Wielopolski, Agnita J.W. Boon, J.H. Paul Wilson, Rob M. Verdijk, Sipeng Zheng, Sylvestre Bonnet, Lucia Bossoni, Louise van der Weerd, Juan A. Hernandez-Tamames, Janneke G. Langendonk
Format: article
Language:EN
Published: Elsevier 2021
Subjects:
Aceruloplasminemia
Neurodegeneration with brain iron accumulation (NBIA)
Postmortem MRI
Iron
Transverse relaxation rate (R2*)
Susceptibility
Neurosciences. Biological psychiatry. Neuropsychiatry
RC321-571
Online Access:https://doaj.org/article/25680c7f65bc474789a8738d5494e084
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https://doaj.org/article/25680c7f65bc474789a8738d5494e084

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