Computational protein design quantifies structural constraints on amino acid covariation.

Amino acid covariation, where the identities of amino acids at different sequence positions are correlated, is a hallmark of naturally occurring proteins. This covariation can arise from multiple factors, including selective pressures for maintaining protein structure, requirements imposed by a spec...

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Auteurs principaux: Noah Ollikainen, Tanja Kortemme
Format: article
Langue:EN
Publié: Public Library of Science (PLoS) 2013
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Accès en ligne:https://doaj.org/article/25c6e0753bb14072b6fa8d7f87178cc2
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