Depleting components of the THO complex causes increased telomere length by reducing the expression of the telomere-associated protein Rif1p.

Telomere length is regulated mostly by proteins directly associated with telomeres. However, genome-wide analysis of Saccharomyces cerevisiae mutants has revealed that deletion of Hpr1p, a component of the THO complex, also affects telomere length. The THO complex comprises four protein subunits, na...

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Autores principales: Tai-Yuan Yu, Chen-Yi Wang, Jing-Jer Lin
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2012
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Acceso en línea:https://doaj.org/article/25ca8111daf74d6587dd0262103ddffb
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