Screening of small molecules using the inhibition of oligomer formation in α-synuclein aggregation as a selection parameter

Promising treatments for neurogenerative disorders may involve targeting kinetic intermediates, including α-synuclein oligomers. Here a kinetic method for quantifying oligomer populations is used to screen small molecule inhibitors of oligomerisation and gain mechanistic insight into their modes of...

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Auteurs principaux:	Roxine Staats, Thomas C. T. Michaels, Patrick Flagmeier, Sean Chia, Robert I. Horne, Johnny Habchi, Sara Linse, Tuomas P. J. Knowles, Christopher M. Dobson, Michele Vendruscolo
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2020
Sujets:	Chemistry QD1-999
Accès en ligne:	https://doaj.org/article/25cc20ef6fa54796a866e8e34065ca87
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spelling	oai:doaj.org-article:25cc20ef6fa54796a866e8e34065ca872021-12-02T12:41:24ZScreening of small molecules using the inhibition of oligomer formation in α-synuclein aggregation as a selection parameter10.1038/s42004-020-00412-y2399-3669https://doaj.org/article/25cc20ef6fa54796a866e8e34065ca872020-12-01T00:00:00Zhttps://doi.org/10.1038/s42004-020-00412-yhttps://doaj.org/toc/2399-3669Promising treatments for neurogenerative disorders may involve targeting kinetic intermediates, including α-synuclein oligomers. Here a kinetic method for quantifying oligomer populations is used to screen small molecule inhibitors of oligomerisation and gain mechanistic insight into their modes of action.Roxine StaatsThomas C. T. MichaelsPatrick FlagmeierSean ChiaRobert I. HorneJohnny HabchiSara LinseTuomas P. J. KnowlesChristopher M. DobsonMichele VendruscoloNature PortfolioarticleChemistryQD1-999ENCommunications Chemistry, Vol 3, Iss 1, Pp 1-9 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Chemistry QD1-999
spellingShingle	Chemistry QD1-999 Roxine Staats Thomas C. T. Michaels Patrick Flagmeier Sean Chia Robert I. Horne Johnny Habchi Sara Linse Tuomas P. J. Knowles Christopher M. Dobson Michele Vendruscolo Screening of small molecules using the inhibition of oligomer formation in α-synuclein aggregation as a selection parameter
description	Promising treatments for neurogenerative disorders may involve targeting kinetic intermediates, including α-synuclein oligomers. Here a kinetic method for quantifying oligomer populations is used to screen small molecule inhibitors of oligomerisation and gain mechanistic insight into their modes of action.
format	article
author	Roxine Staats Thomas C. T. Michaels Patrick Flagmeier Sean Chia Robert I. Horne Johnny Habchi Sara Linse Tuomas P. J. Knowles Christopher M. Dobson Michele Vendruscolo
author_facet	Roxine Staats Thomas C. T. Michaels Patrick Flagmeier Sean Chia Robert I. Horne Johnny Habchi Sara Linse Tuomas P. J. Knowles Christopher M. Dobson Michele Vendruscolo
author_sort	Roxine Staats
title	Screening of small molecules using the inhibition of oligomer formation in α-synuclein aggregation as a selection parameter
title_short	Screening of small molecules using the inhibition of oligomer formation in α-synuclein aggregation as a selection parameter
title_full	Screening of small molecules using the inhibition of oligomer formation in α-synuclein aggregation as a selection parameter
title_fullStr	Screening of small molecules using the inhibition of oligomer formation in α-synuclein aggregation as a selection parameter
title_full_unstemmed	Screening of small molecules using the inhibition of oligomer formation in α-synuclein aggregation as a selection parameter
title_sort	screening of small molecules using the inhibition of oligomer formation in α-synuclein aggregation as a selection parameter
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/25cc20ef6fa54796a866e8e34065ca87
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Screening of small molecules using the inhibition of oligomer formation in α-synuclein aggregation as a selection parameter

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