Primary microcephaly gene MCPH1 shows signatures of tumor suppressors and is regulated by miR-27a in oral squamous cell carcinoma.

Mutations in the MCPH1 (microcephalin 1) gene, located at chromosome 8p23.1, result in two autosomal recessive disorders: primary microcephaly and premature chromosome condensation syndrome. MCPH1 has also been shown to be downregulated in breast, prostate and ovarian cancers, and mutated in 1/10 br...

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Autores principales: Thejaswini Venkatesh, Mathighatta Nagaraj Nagashri, Shivananda S Swamy, S M Azeem Mohiyuddin, Kodaganur S Gopinath, Arun Kumar
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2013
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Acceso en línea:https://doaj.org/article/25cf670f2246497ab634250d4dfb0b92
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