Aberrant DNA methylation of Tgfb1 in diabetic kidney mesangial cells

Aberrant DNA methylation of Tgfb1 in diabetic kidney mesangial cells

Abstract Epigenetic modulation may underlie the progression of diabetic nephropathy (DN). Involvement of TGFB1 in mesangial fibrosis of DN led us to hypothesize that Tgfb1 DNA demethylation contributes to progression of DN. In primary mesangial cells from diabetic (db/db) mouse kidneys, demethylatio...

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Auteurs principaux: Shigeyoshi Oba, Nobuhiro Ayuzawa, Mitsuhiro Nishimoto, Wakako Kawarazaki, Kohei Ueda, Daigoro Hirohama, Fumiko Kawakami-Mori, Tatsuo Shimosawa, Takeshi Marumo, Toshiro Fujita
Format: article
Langue:EN
Publié: Nature Portfolio 2018
Sujets:
Primary Mesangial Cells
TGFB1 Promoter
Mesangial Fibrosis
TGFβ1 mRNA Expression
USF Binding Site
Medicine
R
Science
Q
Accès en ligne:https://doaj.org/article/25e25c0186854cdaaea68a964729952f
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https://doaj.org/article/25e25c0186854cdaaea68a964729952f

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