Aberrant DNA methylation of Tgfb1 in diabetic kidney mesangial cells

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Aberrant DNA methylation of Tgfb1 in diabetic kidney mesangial cells

Abstract Epigenetic modulation may underlie the progression of diabetic nephropathy (DN). Involvement of TGFB1 in mesangial fibrosis of DN led us to hypothesize that Tgfb1 DNA demethylation contributes to progression of DN. In primary mesangial cells from diabetic (db/db) mouse kidneys, demethylatio...

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Autores principales:	Shigeyoshi Oba, Nobuhiro Ayuzawa, Mitsuhiro Nishimoto, Wakako Kawarazaki, Kohei Ueda, Daigoro Hirohama, Fumiko Kawakami-Mori, Tatsuo Shimosawa, Takeshi Marumo, Toshiro Fujita
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Primary Mesangial Cells TGFB1 Promoter Mesangial Fibrosis TGFβ1 mRNA Expression USF Binding Site Medicine R Science Q
Acceso en línea:	https://doaj.org/article/25e25c0186854cdaaea68a964729952f
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

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