Scotoma analysis of 10-2 visual field testing with a white target in screening for hydroxychloroquine retinopathy

David J Browning, Chong Lee Department of Ophthalmology, Charlotte Eye, Ear, Nose and Throat Associates, Charlotte, NC, USA Objective: To quantify the variability of scotomas detected by 10-2 visual field (VF) testing in patients taking hydroxychloroquine without and with retinopathy.Design: Retro...

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Autores principales: Browning DJ, Lee C
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Publicado: Dove Medical Press 2015
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spelling oai:doaj.org-article:25f75625e1354a59bdcf9310301929032021-12-02T01:56:38ZScotoma analysis of 10-2 visual field testing with a white target in screening for hydroxychloroquine retinopathy1177-5483https://doaj.org/article/25f75625e1354a59bdcf9310301929032015-05-01T00:00:00Zhttp://www.dovepress.com/scotoma-analysis-of-10-2-visual-field-testing-with-a-white-target-in-s-peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483David J Browning, Chong Lee Department of Ophthalmology, Charlotte Eye, Ear, Nose and Throat Associates, Charlotte, NC, USA Objective: To quantify the variability of scotomas detected by 10-2 visual field (VF) testing in patients taking hydroxychloroquine without and with retinopathy.Design: Retrospective review of clinical charts and visual fields.Subjects: Twenty-one patients taking hydroxychloroquine without retinopathy, and nine patients taking hydroxychloroquine and one patient taking chloroquine with retinopathy.Methods: Retinopathy was defined by annular scotomas on 10-2 VF testing with corroborative spectral domain optical coherence tomographic outer retinal changes and multifocal electroretinographic changes leading to cessation of hydroxychloroquine or chloroquine. Location and depth of scotoma points on 10-2 VF testing were recorded and their fates followed in serial, reliable 10-2 VFs performed with a white target over time.Main outcome measures: Number of scotoma points and locations, percentage of persistent scotoma points, size of scotomas, location of scotomas, and percentage of scotomas deepening.Results: A median of five, interquartile range (IQR) 3–8 scotoma points per VF occurred in patients without retinopathy. A median of 86%, IQR 63%–100% of these points resolve on the subsequent field. For patients with retinopathy, a median of 22%, IQR 10%–59% resolve. The median percentage of scotoma points in the zone 2–8 degrees from fixation in eyes with retinopathy was 79%, IQR 68%–85% compared to 60%, IQR 54%–75% in eyes without retinopathy (P=0.0094). Single-point scotomas were more common in eyes without than with retinopathy. Scotomas consisting of more than four contiguous scotoma points were generally indicative of retinopathy.Conclusion: Point scotomas are common and variable in 10-2 VF testing with a white target for hydroxychloroquine retinopathy in subjects without retinopathy. The annular zone 2 to 8 degrees from fixation was useful for distinguishing the significance of scotoma points. Scotomas with more contiguous scotoma points were more often associated with retinopathy. Keywords: hydroxychloroquine, chloroquine, 10-2 visual field, ideal body weight, toxicity, retinopathyBrowning DJLee CDove Medical PressarticleOphthalmologyRE1-994ENClinical Ophthalmology, Vol 2015, Iss default, Pp 943-952 (2015)
institution DOAJ
collection DOAJ
language EN
topic Ophthalmology
RE1-994
spellingShingle Ophthalmology
RE1-994
Browning DJ
Lee C
Scotoma analysis of 10-2 visual field testing with a white target in screening for hydroxychloroquine retinopathy
description David J Browning, Chong Lee Department of Ophthalmology, Charlotte Eye, Ear, Nose and Throat Associates, Charlotte, NC, USA Objective: To quantify the variability of scotomas detected by 10-2 visual field (VF) testing in patients taking hydroxychloroquine without and with retinopathy.Design: Retrospective review of clinical charts and visual fields.Subjects: Twenty-one patients taking hydroxychloroquine without retinopathy, and nine patients taking hydroxychloroquine and one patient taking chloroquine with retinopathy.Methods: Retinopathy was defined by annular scotomas on 10-2 VF testing with corroborative spectral domain optical coherence tomographic outer retinal changes and multifocal electroretinographic changes leading to cessation of hydroxychloroquine or chloroquine. Location and depth of scotoma points on 10-2 VF testing were recorded and their fates followed in serial, reliable 10-2 VFs performed with a white target over time.Main outcome measures: Number of scotoma points and locations, percentage of persistent scotoma points, size of scotomas, location of scotomas, and percentage of scotomas deepening.Results: A median of five, interquartile range (IQR) 3–8 scotoma points per VF occurred in patients without retinopathy. A median of 86%, IQR 63%–100% of these points resolve on the subsequent field. For patients with retinopathy, a median of 22%, IQR 10%–59% resolve. The median percentage of scotoma points in the zone 2–8 degrees from fixation in eyes with retinopathy was 79%, IQR 68%–85% compared to 60%, IQR 54%–75% in eyes without retinopathy (P=0.0094). Single-point scotomas were more common in eyes without than with retinopathy. Scotomas consisting of more than four contiguous scotoma points were generally indicative of retinopathy.Conclusion: Point scotomas are common and variable in 10-2 VF testing with a white target for hydroxychloroquine retinopathy in subjects without retinopathy. The annular zone 2 to 8 degrees from fixation was useful for distinguishing the significance of scotoma points. Scotomas with more contiguous scotoma points were more often associated with retinopathy. Keywords: hydroxychloroquine, chloroquine, 10-2 visual field, ideal body weight, toxicity, retinopathy
format article
author Browning DJ
Lee C
author_facet Browning DJ
Lee C
author_sort Browning DJ
title Scotoma analysis of 10-2 visual field testing with a white target in screening for hydroxychloroquine retinopathy
title_short Scotoma analysis of 10-2 visual field testing with a white target in screening for hydroxychloroquine retinopathy
title_full Scotoma analysis of 10-2 visual field testing with a white target in screening for hydroxychloroquine retinopathy
title_fullStr Scotoma analysis of 10-2 visual field testing with a white target in screening for hydroxychloroquine retinopathy
title_full_unstemmed Scotoma analysis of 10-2 visual field testing with a white target in screening for hydroxychloroquine retinopathy
title_sort scotoma analysis of 10-2 visual field testing with a white target in screening for hydroxychloroquine retinopathy
publisher Dove Medical Press
publishDate 2015
url https://doaj.org/article/25f75625e1354a59bdcf931030192903
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