β4GALT1 controls β1 integrin function to govern thrombopoiesis and hematopoietic stem cell homeostasis

β4GALT1 controls β1 integrin function to govern thrombopoiesis and hematopoietic stem cell homeostasis

Mutations affecting sialylation and galactosylation affect megakaryocyte function and thrombopoiesis. Here the authors show that the enzyme β4GalT1 regulates thrombopoiesis and hematopoietic stem cell homeostasis by controlling beta-1 integrin function.

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Bibliographic Details
Main Authors: Silvia Giannini, Melissa M. Lee-Sundlov, Leonardo Rivadeneyra, Christian A. Di Buduo, Robert Burns, Joseph T. Lau, Hervé Falet, Alessandra Balduini, Karin M. Hoffmeister
Format: article
Language:EN
Published: Nature Portfolio 2020
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Science
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Online Access:https://doaj.org/article/260eeeaaa02b43dda46cc8c8f666fa3c
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https://doaj.org/article/260eeeaaa02b43dda46cc8c8f666fa3c

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