Phf8 loss confers resistance to depression-like and anxiety-like behaviors in mice

Phf8 loss confers resistance to depression-like and anxiety-like behaviors in mice

Mutation of the human genePHF8, encoding a histone demethylase, is linked to cognitive defects but its role in development is unclear. Here, the authors show that Phf8deletion in mice causes no overt developmental defects but confers resilience to depression, likely through increased serotonin signa...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Ryan M. Walsh, Erica Y. Shen, Rosemary C. Bagot, Anthony Anselmo, Yan Jiang, Behnam Javidfar, Gregory J. Wojtkiewicz, Jennifer Cloutier, John W. Chen, Ruslan Sadreyev, Eric J. Nestler, Schahram Akbarian, Konrad Hochedlinger
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
Materias:
Science
Q
Acceso en línea:https://doaj.org/article/261ca9d8da8c4c53b1a7c7d577c757f8
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!

Internet

https://doaj.org/article/261ca9d8da8c4c53b1a7c7d577c757f8

Ejemplares similares