Phf8 loss confers resistance to depression-like and anxiety-like behaviors in mice

Mutation of the human genePHF8, encoding a histone demethylase, is linked to cognitive defects but its role in development is unclear. Here, the authors show that Phf8deletion in mice causes no overt developmental defects but confers resilience to depression, likely through increased serotonin signa...

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Autores principales:	Ryan M. Walsh, Erica Y. Shen, Rosemary C. Bagot, Anthony Anselmo, Yan Jiang, Behnam Javidfar, Gregory J. Wojtkiewicz, Jennifer Cloutier, John W. Chen, Ruslan Sadreyev, Eric J. Nestler, Schahram Akbarian, Konrad Hochedlinger
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/261ca9d8da8c4c53b1a7c7d577c757f8
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spelling	oai:doaj.org-article:261ca9d8da8c4c53b1a7c7d577c757f82021-12-02T14:41:18ZPhf8 loss confers resistance to depression-like and anxiety-like behaviors in mice10.1038/ncomms151422041-1723https://doaj.org/article/261ca9d8da8c4c53b1a7c7d577c757f82017-05-01T00:00:00Zhttps://doi.org/10.1038/ncomms15142https://doaj.org/toc/2041-1723Mutation of the human genePHF8, encoding a histone demethylase, is linked to cognitive defects but its role in development is unclear. Here, the authors show that Phf8deletion in mice causes no overt developmental defects but confers resilience to depression, likely through increased serotonin signalling.Ryan M. WalshErica Y. ShenRosemary C. BagotAnthony AnselmoYan JiangBehnam JavidfarGregory J. WojtkiewiczJennifer CloutierJohn W. ChenRuslan SadreyevEric J. NestlerSchahram AkbarianKonrad HochedlingerNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ryan M. Walsh Erica Y. Shen Rosemary C. Bagot Anthony Anselmo Yan Jiang Behnam Javidfar Gregory J. Wojtkiewicz Jennifer Cloutier John W. Chen Ruslan Sadreyev Eric J. Nestler Schahram Akbarian Konrad Hochedlinger Phf8 loss confers resistance to depression-like and anxiety-like behaviors in mice
description	Mutation of the human genePHF8, encoding a histone demethylase, is linked to cognitive defects but its role in development is unclear. Here, the authors show that Phf8deletion in mice causes no overt developmental defects but confers resilience to depression, likely through increased serotonin signalling.
format	article
author	Ryan M. Walsh Erica Y. Shen Rosemary C. Bagot Anthony Anselmo Yan Jiang Behnam Javidfar Gregory J. Wojtkiewicz Jennifer Cloutier John W. Chen Ruslan Sadreyev Eric J. Nestler Schahram Akbarian Konrad Hochedlinger
author_facet	Ryan M. Walsh Erica Y. Shen Rosemary C. Bagot Anthony Anselmo Yan Jiang Behnam Javidfar Gregory J. Wojtkiewicz Jennifer Cloutier John W. Chen Ruslan Sadreyev Eric J. Nestler Schahram Akbarian Konrad Hochedlinger
author_sort	Ryan M. Walsh
title	Phf8 loss confers resistance to depression-like and anxiety-like behaviors in mice
title_short	Phf8 loss confers resistance to depression-like and anxiety-like behaviors in mice
title_full	Phf8 loss confers resistance to depression-like and anxiety-like behaviors in mice
title_fullStr	Phf8 loss confers resistance to depression-like and anxiety-like behaviors in mice
title_full_unstemmed	Phf8 loss confers resistance to depression-like and anxiety-like behaviors in mice
title_sort	phf8 loss confers resistance to depression-like and anxiety-like behaviors in mice
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/261ca9d8da8c4c53b1a7c7d577c757f8
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Phf8 loss confers resistance to depression-like and anxiety-like behaviors in mice

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