A knock-in Npm1 mutation in mice results in myeloproliferation and implies a perturbation in hematopoietic microenvironment.

A knock-in Npm1 mutation in mice results in myeloproliferation and implies a perturbation in hematopoietic microenvironment.

Somatic Nucleophosmin (NPM1) mutation frequently occurs in acute myeloid leukemia (AML), but its role in leukemogenesis remains unclear. This study reports the first "conventional" knock-in mouse model of Npm1 mutation, which was achieved by inserting TCTG after nucleotide c.857 (c.854_857...

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Autores principales: Shiu-Huey Chou, Bor-Sheng Ko, Ji-Shain Chiou, Yueh-Chwen Hsu, Mong-Hsun Tsai, Yu-Chiao Chiu, I-Shing Yu, Shu-Wha Lin, Hsin-An Hou, Yi-Yi Kuo, Hsiu-Mei Lin, Ming-Fang Wu, Wen-Chien Chou, Hwei-Fang Tien
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2012
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/262fc84479174d8fb6661022bcaf3629
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