An NS-segment exonic splicing enhancer regulates influenza A virus replication in mammalian cells

An NS-segment exonic splicing enhancer regulates influenza A virus replication in mammalian cells

Some circulating avian influenza A viruses can infect humans, but the mechanism enabling species jump is poorly understood. Here, Huanget al. identify a nucleotide in NEP of avian H7N9 viruses that affects splicing efficiency of the NS segment and supports virus replication in avian and mammalian ce...

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Autores principales: Xiaofeng Huang, Min Zheng, Pui Wang, Bobo Wing-Yee Mok, Siwen Liu, Siu-Ying Lau, Pin Chen, Yen-Chin Liu, Honglian Liu, Yixin Chen, Wenjun Song, Kwok-Yung Yuen, Honglin Chen
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/2633172c87034f53bb00b4b09dbedbec
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spelling oai:doaj.org-article:2633172c87034f53bb00b4b09dbedbec2021-12-02T14:40:34ZAn NS-segment exonic splicing enhancer regulates influenza A virus replication in mammalian cells10.1038/ncomms147512041-1723https://doaj.org/article/2633172c87034f53bb00b4b09dbedbec2017-03-01T00:00:00Zhttps://doi.org/10.1038/ncomms14751https://doaj.org/toc/2041-1723Some circulating avian influenza A viruses can infect humans, but the mechanism enabling species jump is poorly understood. Here, Huanget al. identify a nucleotide in NEP of avian H7N9 viruses that affects splicing efficiency of the NS segment and supports virus replication in avian and mammalian cells.Xiaofeng HuangMin ZhengPui WangBobo Wing-Yee MokSiwen LiuSiu-Ying LauPin ChenYen-Chin LiuHonglian LiuYixin ChenWenjun SongKwok-Yung YuenHonglin ChenNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Xiaofeng Huang
Min Zheng
Pui Wang
Bobo Wing-Yee Mok
Siwen Liu
Siu-Ying Lau
Pin Chen
Yen-Chin Liu
Honglian Liu
Yixin Chen
Wenjun Song
Kwok-Yung Yuen
Honglin Chen
An NS-segment exonic splicing enhancer regulates influenza A virus replication in mammalian cells
description Some circulating avian influenza A viruses can infect humans, but the mechanism enabling species jump is poorly understood. Here, Huanget al. identify a nucleotide in NEP of avian H7N9 viruses that affects splicing efficiency of the NS segment and supports virus replication in avian and mammalian cells.
format article
author Xiaofeng Huang
Min Zheng
Pui Wang
Bobo Wing-Yee Mok
Siwen Liu
Siu-Ying Lau
Pin Chen
Yen-Chin Liu
Honglian Liu
Yixin Chen
Wenjun Song
Kwok-Yung Yuen
Honglin Chen
author_facet Xiaofeng Huang
Min Zheng
Pui Wang
Bobo Wing-Yee Mok
Siwen Liu
Siu-Ying Lau
Pin Chen
Yen-Chin Liu
Honglian Liu
Yixin Chen
Wenjun Song
Kwok-Yung Yuen
Honglin Chen
author_sort Xiaofeng Huang
title An NS-segment exonic splicing enhancer regulates influenza A virus replication in mammalian cells
title_short An NS-segment exonic splicing enhancer regulates influenza A virus replication in mammalian cells
title_full An NS-segment exonic splicing enhancer regulates influenza A virus replication in mammalian cells
title_fullStr An NS-segment exonic splicing enhancer regulates influenza A virus replication in mammalian cells
title_full_unstemmed An NS-segment exonic splicing enhancer regulates influenza A virus replication in mammalian cells
title_sort ns-segment exonic splicing enhancer regulates influenza a virus replication in mammalian cells
publisher Nature Portfolio
publishDate 2017
url https://doaj.org/article/2633172c87034f53bb00b4b09dbedbec
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