Human iPSC-derived mature microglia retain their identity and functionally integrate in the chimeric mouse brain

Human microglia present unique features; therefore, chimeric mouse models can enhance modelling of human microglia response in health and disease. Here, the authors show that hiPSC-derived mature microglia developed in the mouse brain, retain their identity and respond to demyelination.

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Autores principales: Ranjie Xu, Xiaoxi Li, Andrew J. Boreland, Anthony Posyton, Kelvin Kwan, Ronald P. Hart, Peng Jiang
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/263c025eeb5a4353bd524f6f00f63e13
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