Human iPSC-derived mature microglia retain their identity and functionally integrate in the chimeric mouse brain

Human iPSC-derived mature microglia retain their identity and functionally integrate in the chimeric mouse brain

Human microglia present unique features; therefore, chimeric mouse models can enhance modelling of human microglia response in health and disease. Here, the authors show that hiPSC-derived mature microglia developed in the mouse brain, retain their identity and respond to demyelination.

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Autores principales: Ranjie Xu, Xiaoxi Li, Andrew J. Boreland, Anthony Posyton, Kelvin Kwan, Ronald P. Hart, Peng Jiang
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/263c025eeb5a4353bd524f6f00f63e13
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spelling oai:doaj.org-article:263c025eeb5a4353bd524f6f00f63e132021-12-02T14:41:25ZHuman iPSC-derived mature microglia retain their identity and functionally integrate in the chimeric mouse brain10.1038/s41467-020-15411-92041-1723https://doaj.org/article/263c025eeb5a4353bd524f6f00f63e132020-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15411-9https://doaj.org/toc/2041-1723Human microglia present unique features; therefore, chimeric mouse models can enhance modelling of human microglia response in health and disease. Here, the authors show that hiPSC-derived mature microglia developed in the mouse brain, retain their identity and respond to demyelination.Ranjie XuXiaoxi LiAndrew J. BorelandAnthony PosytonKelvin KwanRonald P. HartPeng JiangNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Ranjie Xu
Xiaoxi Li
Andrew J. Boreland
Anthony Posyton
Kelvin Kwan
Ronald P. Hart
Peng Jiang
Human iPSC-derived mature microglia retain their identity and functionally integrate in the chimeric mouse brain
description Human microglia present unique features; therefore, chimeric mouse models can enhance modelling of human microglia response in health and disease. Here, the authors show that hiPSC-derived mature microglia developed in the mouse brain, retain their identity and respond to demyelination.
format article
author Ranjie Xu
Xiaoxi Li
Andrew J. Boreland
Anthony Posyton
Kelvin Kwan
Ronald P. Hart
Peng Jiang
author_facet Ranjie Xu
Xiaoxi Li
Andrew J. Boreland
Anthony Posyton
Kelvin Kwan
Ronald P. Hart
Peng Jiang
author_sort Ranjie Xu
title Human iPSC-derived mature microglia retain their identity and functionally integrate in the chimeric mouse brain
title_short Human iPSC-derived mature microglia retain their identity and functionally integrate in the chimeric mouse brain
title_full Human iPSC-derived mature microglia retain their identity and functionally integrate in the chimeric mouse brain
title_fullStr Human iPSC-derived mature microglia retain their identity and functionally integrate in the chimeric mouse brain
title_full_unstemmed Human iPSC-derived mature microglia retain their identity and functionally integrate in the chimeric mouse brain
title_sort human ipsc-derived mature microglia retain their identity and functionally integrate in the chimeric mouse brain
publisher Nature Portfolio
publishDate 2020
url https://doaj.org/article/263c025eeb5a4353bd524f6f00f63e13
work_keys_str_mv AT ranjiexu humanipscderivedmaturemicrogliaretaintheiridentityandfunctionallyintegrateinthechimericmousebrain
AT xiaoxili humanipscderivedmaturemicrogliaretaintheiridentityandfunctionallyintegrateinthechimericmousebrain
AT andrewjboreland humanipscderivedmaturemicrogliaretaintheiridentityandfunctionallyintegrateinthechimericmousebrain
AT anthonyposyton humanipscderivedmaturemicrogliaretaintheiridentityandfunctionallyintegrateinthechimericmousebrain
AT kelvinkwan humanipscderivedmaturemicrogliaretaintheiridentityandfunctionallyintegrateinthechimericmousebrain
AT ronaldphart humanipscderivedmaturemicrogliaretaintheiridentityandfunctionallyintegrateinthechimericmousebrain
AT pengjiang humanipscderivedmaturemicrogliaretaintheiridentityandfunctionallyintegrateinthechimericmousebrain
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