Niemann-Pick C1 Is Essential for Ebolavirus Replication and Pathogenesis <italic toggle="yes">In Vivo</italic>

Niemann-Pick C1 Is Essential for Ebolavirus Replication and Pathogenesis <italic toggle="yes">In Vivo</italic>

ABSTRACT Recent work demonstrated that the Niemann-Pick C1 (NPC1) protein is an essential entry receptor for filoviruses. While previous studies focused on filovirus entry requirements of NPC1 in vitro, its roles in filovirus replication and pathogenesis in vivo remain unclear. Here, we evaluated th...

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Bibliographic Details
Main Authors: Andrew S. Herbert, Cristin Davidson, Ana I. Kuehne, Russell Bakken, Stephen Z. Braigen, Kathryn E. Gunn, Sean P. Whelan, Thijn R. Brummelkamp, Nancy A. Twenhafel, Kartik Chandran, Steven U. Walkley, John M. Dye
Format: article
Language:EN
Published: American Society for Microbiology 2015
Subjects:
Microbiology
QR1-502
Online Access:https://doaj.org/article/263ccfc6711f4321bc9f6e259ae2e4fb
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