Preparation and Characterization of Semi-IPN Cryogels Based on Polyacrylamide and Poly(<i>N</i>,<i>N</i>-dimethylaminoethyl methacrylate); Functionalization of Carrier with Monochlorotriazinyl-β-cyclodextrin and Release Kinetics of Curcumin

Curcumin (CCM) is a natural hydrophobic polyphenol known for its numerous applications in the food industry as a colorant or jelly stabilizer, and in the pharmaceutical industry due to its anti-inflammatory, antibacterial, antioxidant, anti-cancer, and anti-Alzheimer properties. However, the large a...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Ecaterina Stela Dragan, Maria Valentina Dinu, Claudiu Augustin Ghiorghita, Maria Marinela Lazar, Florica Doroftei
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	cryogel poly(acrylamide) poly(<i>N</i>,<i>N</i>-dimethylaminoethylmethacrylate) monochlorotriazinyl-β-cyclodextrin curcumin Organic chemistry QD241-441
Acceso en línea:	https://doaj.org/article/264d0236e9984a6fb88b57da4309f778
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:264d0236e9984a6fb88b57da4309f778
record_format	dspace
spelling	oai:doaj.org-article:264d0236e9984a6fb88b57da4309f7782021-11-25T18:28:51ZPreparation and Characterization of Semi-IPN Cryogels Based on Polyacrylamide and Poly(<i>N</i>,<i>N</i>-dimethylaminoethyl methacrylate); Functionalization of Carrier with Monochlorotriazinyl-β-cyclodextrin and Release Kinetics of Curcumin10.3390/molecules262269751420-3049https://doaj.org/article/264d0236e9984a6fb88b57da4309f7782021-11-01T00:00:00Zhttps://www.mdpi.com/1420-3049/26/22/6975https://doaj.org/toc/1420-3049Curcumin (CCM) is a natural hydrophobic polyphenol known for its numerous applications in the food industry as a colorant or jelly stabilizer, and in the pharmaceutical industry due to its anti-inflammatory, antibacterial, antioxidant, anti-cancer, and anti-Alzheimer properties. However, the large application of CCM is limited by its poor solubility in water and low stability. To enhance the bioavailability of CCM, and to protect it against the external degradation agents, a novel strategy, which consists in the preparation of semi-interpenetrating polymer networks, (s-IPNs) based on poly(<i>N</i>,<i>N</i>-dimethylaminoethyl methacrylate) entrapped in poly(acrylamide) networks, by a cryogelation technique, was developed in this work. All s-IPN cryogels were characterized by SEM, EDX, FTIR, and swelling at equilibrium as a function of pH. Functionalization of semi-IPN cryogel with monochlorotriazinyl-β-cyclodextrin (MCT-β-CD) led to IPN cryogel. The release profile of CCM from the composite cryogels was investigated at 37 °C, in pH 3. It was found that the cumulative release increased with the increase of the carrier hydrophobicity, as a result of increasing the cross-linking degree, the content and the molar mass of PDMAEMA. Fitting Higuchi, Korsmeyer–Peppas, and first order kinetic models on the CCM release profiles indicated the diffusion as the main driving force of drug release from the composite cryogels.Ecaterina Stela DraganMaria Valentina DinuClaudiu Augustin GhiorghitaMaria Marinela LazarFlorica DorofteiMDPI AGarticlecryogelpoly(acrylamide)poly(<i>N</i>,<i>N</i>-dimethylaminoethylmethacrylate)monochlorotriazinyl-β-cyclodextrincurcuminOrganic chemistryQD241-441ENMolecules, Vol 26, Iss 6975, p 6975 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	cryogel poly(acrylamide) poly(<i>N</i>,<i>N</i>-dimethylaminoethylmethacrylate) monochlorotriazinyl-β-cyclodextrin curcumin Organic chemistry QD241-441
spellingShingle	cryogel poly(acrylamide) poly(<i>N</i>,<i>N</i>-dimethylaminoethylmethacrylate) monochlorotriazinyl-β-cyclodextrin curcumin Organic chemistry QD241-441 Ecaterina Stela Dragan Maria Valentina Dinu Claudiu Augustin Ghiorghita Maria Marinela Lazar Florica Doroftei Preparation and Characterization of Semi-IPN Cryogels Based on Polyacrylamide and Poly(<i>N</i>,<i>N</i>-dimethylaminoethyl methacrylate); Functionalization of Carrier with Monochlorotriazinyl-β-cyclodextrin and Release Kinetics of Curcumin
description	Curcumin (CCM) is a natural hydrophobic polyphenol known for its numerous applications in the food industry as a colorant or jelly stabilizer, and in the pharmaceutical industry due to its anti-inflammatory, antibacterial, antioxidant, anti-cancer, and anti-Alzheimer properties. However, the large application of CCM is limited by its poor solubility in water and low stability. To enhance the bioavailability of CCM, and to protect it against the external degradation agents, a novel strategy, which consists in the preparation of semi-interpenetrating polymer networks, (s-IPNs) based on poly(<i>N</i>,<i>N</i>-dimethylaminoethyl methacrylate) entrapped in poly(acrylamide) networks, by a cryogelation technique, was developed in this work. All s-IPN cryogels were characterized by SEM, EDX, FTIR, and swelling at equilibrium as a function of pH. Functionalization of semi-IPN cryogel with monochlorotriazinyl-β-cyclodextrin (MCT-β-CD) led to IPN cryogel. The release profile of CCM from the composite cryogels was investigated at 37 °C, in pH 3. It was found that the cumulative release increased with the increase of the carrier hydrophobicity, as a result of increasing the cross-linking degree, the content and the molar mass of PDMAEMA. Fitting Higuchi, Korsmeyer–Peppas, and first order kinetic models on the CCM release profiles indicated the diffusion as the main driving force of drug release from the composite cryogels.
format	article
author	Ecaterina Stela Dragan Maria Valentina Dinu Claudiu Augustin Ghiorghita Maria Marinela Lazar Florica Doroftei
author_facet	Ecaterina Stela Dragan Maria Valentina Dinu Claudiu Augustin Ghiorghita Maria Marinela Lazar Florica Doroftei
author_sort	Ecaterina Stela Dragan
title	Preparation and Characterization of Semi-IPN Cryogels Based on Polyacrylamide and Poly(<i>N</i>,<i>N</i>-dimethylaminoethyl methacrylate); Functionalization of Carrier with Monochlorotriazinyl-β-cyclodextrin and Release Kinetics of Curcumin
title_short	Preparation and Characterization of Semi-IPN Cryogels Based on Polyacrylamide and Poly(<i>N</i>,<i>N</i>-dimethylaminoethyl methacrylate); Functionalization of Carrier with Monochlorotriazinyl-β-cyclodextrin and Release Kinetics of Curcumin
title_full	Preparation and Characterization of Semi-IPN Cryogels Based on Polyacrylamide and Poly(<i>N</i>,<i>N</i>-dimethylaminoethyl methacrylate); Functionalization of Carrier with Monochlorotriazinyl-β-cyclodextrin and Release Kinetics of Curcumin
title_fullStr	Preparation and Characterization of Semi-IPN Cryogels Based on Polyacrylamide and Poly(<i>N</i>,<i>N</i>-dimethylaminoethyl methacrylate); Functionalization of Carrier with Monochlorotriazinyl-β-cyclodextrin and Release Kinetics of Curcumin
title_full_unstemmed	Preparation and Characterization of Semi-IPN Cryogels Based on Polyacrylamide and Poly(<i>N</i>,<i>N</i>-dimethylaminoethyl methacrylate); Functionalization of Carrier with Monochlorotriazinyl-β-cyclodextrin and Release Kinetics of Curcumin
title_sort	preparation and characterization of semi-ipn cryogels based on polyacrylamide and poly(<i>n</i>,<i>n</i>-dimethylaminoethyl methacrylate); functionalization of carrier with monochlorotriazinyl-β-cyclodextrin and release kinetics of curcumin
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/264d0236e9984a6fb88b57da4309f778
work_keys_str_mv	AT ecaterinasteladragan preparationandcharacterizationofsemiipncryogelsbasedonpolyacrylamideandpolyiniinidimethylaminoethylmethacrylatefunctionalizationofcarrierwithmonochlorotriazinylbcyclodextrinandreleasekineticsofcurcumin AT mariavalentinadinu preparationandcharacterizationofsemiipncryogelsbasedonpolyacrylamideandpolyiniinidimethylaminoethylmethacrylatefunctionalizationofcarrierwithmonochlorotriazinylbcyclodextrinandreleasekineticsofcurcumin AT claudiuaugustinghiorghita preparationandcharacterizationofsemiipncryogelsbasedonpolyacrylamideandpolyiniinidimethylaminoethylmethacrylatefunctionalizationofcarrierwithmonochlorotriazinylbcyclodextrinandreleasekineticsofcurcumin AT mariamarinelalazar preparationandcharacterizationofsemiipncryogelsbasedonpolyacrylamideandpolyiniinidimethylaminoethylmethacrylatefunctionalizationofcarrierwithmonochlorotriazinylbcyclodextrinandreleasekineticsofcurcumin AT floricadoroftei preparationandcharacterizationofsemiipncryogelsbasedonpolyacrylamideandpolyiniinidimethylaminoethylmethacrylatefunctionalizationofcarrierwithmonochlorotriazinylbcyclodextrinandreleasekineticsofcurcumin
_version_	1718411063702061056

Preparation and Characterization of Semi-IPN Cryogels Based on Polyacrylamide and Poly(<i>N</i>,<i>N</i>-dimethylaminoethyl methacrylate); Functionalization of Carrier with Monochlorotriazinyl-β-cyclodextrin and Release Kinetics of Curcumin

Ejemplares similares