The signalling conformation of the insulin receptor ectodomain

The insulin receptor plays a key role in many physiological processes, yet how insulin effects receptor signaling at the structural level remains incomplete. Here the authors present a high-resolution cryo-EM structure of a high-affinity form of the insulin-bound insulin receptor ectodomain that she...

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Autores principales: Felix Weis, John G. Menting, Mai B. Margetts, Shu Jin Chan, Yibin Xu, Norbert Tennagels, Paulus Wohlfart, Thomas Langer, Christoph W. Müller, Matthias K. Dreyer, Michael C. Lawrence
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/26514aec68da4bd983dcd057a121b978
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