The signalling conformation of the insulin receptor ectodomain

The insulin receptor plays a key role in many physiological processes, yet how insulin effects receptor signaling at the structural level remains incomplete. Here the authors present a high-resolution cryo-EM structure of a high-affinity form of the insulin-bound insulin receptor ectodomain that she...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Felix Weis, John G. Menting, Mai B. Margetts, Shu Jin Chan, Yibin Xu, Norbert Tennagels, Paulus Wohlfart, Thomas Langer, Christoph W. Müller, Matthias K. Dreyer, Michael C. Lawrence
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/26514aec68da4bd983dcd057a121b978
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:26514aec68da4bd983dcd057a121b978
record_format	dspace
spelling	oai:doaj.org-article:26514aec68da4bd983dcd057a121b9782021-12-02T17:32:29ZThe signalling conformation of the insulin receptor ectodomain10.1038/s41467-018-06826-62041-1723https://doaj.org/article/26514aec68da4bd983dcd057a121b9782018-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06826-6https://doaj.org/toc/2041-1723The insulin receptor plays a key role in many physiological processes, yet how insulin effects receptor signaling at the structural level remains incomplete. Here the authors present a high-resolution cryo-EM structure of a high-affinity form of the insulin-bound insulin receptor ectodomain that sheds light on the mechanism of signal transduction.Felix WeisJohn G. MentingMai B. MargettsShu Jin ChanYibin XuNorbert TennagelsPaulus WohlfartThomas LangerChristoph W. MüllerMatthias K. DreyerMichael C. LawrenceNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Felix Weis John G. Menting Mai B. Margetts Shu Jin Chan Yibin Xu Norbert Tennagels Paulus Wohlfart Thomas Langer Christoph W. Müller Matthias K. Dreyer Michael C. Lawrence The signalling conformation of the insulin receptor ectodomain
description	The insulin receptor plays a key role in many physiological processes, yet how insulin effects receptor signaling at the structural level remains incomplete. Here the authors present a high-resolution cryo-EM structure of a high-affinity form of the insulin-bound insulin receptor ectodomain that sheds light on the mechanism of signal transduction.
format	article
author	Felix Weis John G. Menting Mai B. Margetts Shu Jin Chan Yibin Xu Norbert Tennagels Paulus Wohlfart Thomas Langer Christoph W. Müller Matthias K. Dreyer Michael C. Lawrence
author_facet	Felix Weis John G. Menting Mai B. Margetts Shu Jin Chan Yibin Xu Norbert Tennagels Paulus Wohlfart Thomas Langer Christoph W. Müller Matthias K. Dreyer Michael C. Lawrence
author_sort	Felix Weis
title	The signalling conformation of the insulin receptor ectodomain
title_short	The signalling conformation of the insulin receptor ectodomain
title_full	The signalling conformation of the insulin receptor ectodomain
title_fullStr	The signalling conformation of the insulin receptor ectodomain
title_full_unstemmed	The signalling conformation of the insulin receptor ectodomain
title_sort	signalling conformation of the insulin receptor ectodomain
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/26514aec68da4bd983dcd057a121b978
work_keys_str_mv	AT felixweis thesignallingconformationoftheinsulinreceptorectodomain AT johngmenting thesignallingconformationoftheinsulinreceptorectodomain AT maibmargetts thesignallingconformationoftheinsulinreceptorectodomain AT shujinchan thesignallingconformationoftheinsulinreceptorectodomain AT yibinxu thesignallingconformationoftheinsulinreceptorectodomain AT norberttennagels thesignallingconformationoftheinsulinreceptorectodomain AT pauluswohlfart thesignallingconformationoftheinsulinreceptorectodomain AT thomaslanger thesignallingconformationoftheinsulinreceptorectodomain AT christophwmuller thesignallingconformationoftheinsulinreceptorectodomain AT matthiaskdreyer thesignallingconformationoftheinsulinreceptorectodomain AT michaelclawrence thesignallingconformationoftheinsulinreceptorectodomain AT felixweis signallingconformationoftheinsulinreceptorectodomain AT johngmenting signallingconformationoftheinsulinreceptorectodomain AT maibmargetts signallingconformationoftheinsulinreceptorectodomain AT shujinchan signallingconformationoftheinsulinreceptorectodomain AT yibinxu signallingconformationoftheinsulinreceptorectodomain AT norberttennagels signallingconformationoftheinsulinreceptorectodomain AT pauluswohlfart signallingconformationoftheinsulinreceptorectodomain AT thomaslanger signallingconformationoftheinsulinreceptorectodomain AT christophwmuller signallingconformationoftheinsulinreceptorectodomain AT matthiaskdreyer signallingconformationoftheinsulinreceptorectodomain AT michaelclawrence signallingconformationoftheinsulinreceptorectodomain
_version_	1718380235132502016

The signalling conformation of the insulin receptor ectodomain

Ejemplares similares