Single-cell transcriptomics reveals multi-step adaptations to endocrine therapy

Single-cell transcriptomics reveals multi-step adaptations to endocrine therapy

The development of resistance to endocrine therapy is a significant, clinical problem in breast cancer. Here, the authors identify a rare subpopulation of cells that drive resistance following transcriptional reprogramming.

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Autores principales: Sung Pil Hong, Thalia E. Chan, Ylenia Lombardo, Giacomo Corleone, Nicole Rotmensz, Sara Bravaccini, Andrea Rocca, Giancarlo Pruneri, Kirsten R. McEwen, R. Charles Coombes, Iros Barozzi, Luca Magnani
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
Materias:
Science
Q
Acceso en línea:https://doaj.org/article/266ee5cecff04b52b1a25a258b6d6db4
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spelling oai:doaj.org-article:266ee5cecff04b52b1a25a258b6d6db42021-12-02T15:35:14ZSingle-cell transcriptomics reveals multi-step adaptations to endocrine therapy10.1038/s41467-019-11721-92041-1723https://doaj.org/article/266ee5cecff04b52b1a25a258b6d6db42019-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11721-9https://doaj.org/toc/2041-1723The development of resistance to endocrine therapy is a significant, clinical problem in breast cancer. Here, the authors identify a rare subpopulation of cells that drive resistance following transcriptional reprogramming.Sung Pil HongThalia E. ChanYlenia LombardoGiacomo CorleoneNicole RotmenszSara BravacciniAndrea RoccaGiancarlo PruneriKirsten R. McEwenR. Charles CoombesIros BarozziLuca MagnaniNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Sung Pil Hong
Thalia E. Chan
Ylenia Lombardo
Giacomo Corleone
Nicole Rotmensz
Sara Bravaccini
Andrea Rocca
Giancarlo Pruneri
Kirsten R. McEwen
R. Charles Coombes
Iros Barozzi
Luca Magnani
Single-cell transcriptomics reveals multi-step adaptations to endocrine therapy
description The development of resistance to endocrine therapy is a significant, clinical problem in breast cancer. Here, the authors identify a rare subpopulation of cells that drive resistance following transcriptional reprogramming.
format article
author Sung Pil Hong
Thalia E. Chan
Ylenia Lombardo
Giacomo Corleone
Nicole Rotmensz
Sara Bravaccini
Andrea Rocca
Giancarlo Pruneri
Kirsten R. McEwen
R. Charles Coombes
Iros Barozzi
Luca Magnani
author_facet Sung Pil Hong
Thalia E. Chan
Ylenia Lombardo
Giacomo Corleone
Nicole Rotmensz
Sara Bravaccini
Andrea Rocca
Giancarlo Pruneri
Kirsten R. McEwen
R. Charles Coombes
Iros Barozzi
Luca Magnani
author_sort Sung Pil Hong
title Single-cell transcriptomics reveals multi-step adaptations to endocrine therapy
title_short Single-cell transcriptomics reveals multi-step adaptations to endocrine therapy
title_full Single-cell transcriptomics reveals multi-step adaptations to endocrine therapy
title_fullStr Single-cell transcriptomics reveals multi-step adaptations to endocrine therapy
title_full_unstemmed Single-cell transcriptomics reveals multi-step adaptations to endocrine therapy
title_sort single-cell transcriptomics reveals multi-step adaptations to endocrine therapy
publisher Nature Portfolio
publishDate 2019
url https://doaj.org/article/266ee5cecff04b52b1a25a258b6d6db4
work_keys_str_mv AT sungpilhong singlecelltranscriptomicsrevealsmultistepadaptationstoendocrinetherapy
AT thaliaechan singlecelltranscriptomicsrevealsmultistepadaptationstoendocrinetherapy
AT ylenialombardo singlecelltranscriptomicsrevealsmultistepadaptationstoendocrinetherapy
AT giacomocorleone singlecelltranscriptomicsrevealsmultistepadaptationstoendocrinetherapy
AT nicolerotmensz singlecelltranscriptomicsrevealsmultistepadaptationstoendocrinetherapy
AT sarabravaccini singlecelltranscriptomicsrevealsmultistepadaptationstoendocrinetherapy
AT andrearocca singlecelltranscriptomicsrevealsmultistepadaptationstoendocrinetherapy
AT giancarlopruneri singlecelltranscriptomicsrevealsmultistepadaptationstoendocrinetherapy
AT kirstenrmcewen singlecelltranscriptomicsrevealsmultistepadaptationstoendocrinetherapy
AT rcharlescoombes singlecelltranscriptomicsrevealsmultistepadaptationstoendocrinetherapy
AT irosbarozzi singlecelltranscriptomicsrevealsmultistepadaptationstoendocrinetherapy
AT lucamagnani singlecelltranscriptomicsrevealsmultistepadaptationstoendocrinetherapy
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