CryoEM structure of the antibacterial target PBP1b at 3.3 Å resolution

Our structural understanding of class A penicillin binding proteins is incomplete due to the difficulty in their crystallization and the complexity of their substrates. Here, authors determine the structure of the 83 kDa class A PBP from Escherichia coli, PBP1b, using cryogenic electron microscopy a...

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Autores principales:	Nathanael A. Caveney, Sean D. Workman, Rui Yan, Claire E. Atkinson, Zhiheng Yu, Natalie C. J. Strynadka
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/26f4e40c535f443f997600b2ad246b01
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spelling	oai:doaj.org-article:26f4e40c535f443f997600b2ad246b012021-12-02T15:55:07ZCryoEM structure of the antibacterial target PBP1b at 3.3 Å resolution10.1038/s41467-021-23063-62041-1723https://doaj.org/article/26f4e40c535f443f997600b2ad246b012021-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23063-6https://doaj.org/toc/2041-1723Our structural understanding of class A penicillin binding proteins is incomplete due to the difficulty in their crystallization and the complexity of their substrates. Here, authors determine the structure of the 83 kDa class A PBP from Escherichia coli, PBP1b, using cryogenic electron microscopy and a styrene maleic acid anhydride membrane mimetic.Nathanael A. CaveneySean D. WorkmanRui YanClaire E. AtkinsonZhiheng YuNatalie C. J. StrynadkaNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Nathanael A. Caveney Sean D. Workman Rui Yan Claire E. Atkinson Zhiheng Yu Natalie C. J. Strynadka CryoEM structure of the antibacterial target PBP1b at 3.3 Å resolution
description	Our structural understanding of class A penicillin binding proteins is incomplete due to the difficulty in their crystallization and the complexity of their substrates. Here, authors determine the structure of the 83 kDa class A PBP from Escherichia coli, PBP1b, using cryogenic electron microscopy and a styrene maleic acid anhydride membrane mimetic.
format	article
author	Nathanael A. Caveney Sean D. Workman Rui Yan Claire E. Atkinson Zhiheng Yu Natalie C. J. Strynadka
author_facet	Nathanael A. Caveney Sean D. Workman Rui Yan Claire E. Atkinson Zhiheng Yu Natalie C. J. Strynadka
author_sort	Nathanael A. Caveney
title	CryoEM structure of the antibacterial target PBP1b at 3.3 Å resolution
title_short	CryoEM structure of the antibacterial target PBP1b at 3.3 Å resolution
title_full	CryoEM structure of the antibacterial target PBP1b at 3.3 Å resolution
title_fullStr	CryoEM structure of the antibacterial target PBP1b at 3.3 Å resolution
title_full_unstemmed	CryoEM structure of the antibacterial target PBP1b at 3.3 Å resolution
title_sort	cryoem structure of the antibacterial target pbp1b at 3.3 å resolution
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/26f4e40c535f443f997600b2ad246b01
work_keys_str_mv	AT nathanaelacaveney cryoemstructureoftheantibacterialtargetpbp1bat33aresolution AT seandworkman cryoemstructureoftheantibacterialtargetpbp1bat33aresolution AT ruiyan cryoemstructureoftheantibacterialtargetpbp1bat33aresolution AT claireeatkinson cryoemstructureoftheantibacterialtargetpbp1bat33aresolution AT zhihengyu cryoemstructureoftheantibacterialtargetpbp1bat33aresolution AT nataliecjstrynadka cryoemstructureoftheantibacterialtargetpbp1bat33aresolution
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CryoEM structure of the antibacterial target PBP1b at 3.3 Å resolution

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