Pathway design using de novo steps through uncharted biochemical spaces

Existing pathway design tools make use of existing reactions from databases or successively apply retrosynthetic rules. novoStoic provides an integrated optimization-based framework combining known reactions with novel steps in pathway design allowing for constraints on thermodynamic feasibility, pr...

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Autores principales: Akhil Kumar, Lin Wang, Chiam Yu Ng, Costas D. Maranas
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/272f14c7481c4078bb306cbfb36c22dd
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