Activin A more prominently regulates muscle mass in primates than does GDF8

Inhibition of GDF8 increases muscle mass in mice, but is less effective in monkeys and humans. Here the authors show that activin A also inhibits muscle hypertrophy and that concomitant inhibition of activin A and GDF8 synergistically increases muscle mass in mice and non-human primates.

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Autores principales:	Esther Latres, Jason Mastaitis, Wen Fury, Lawrence Miloscio, Jesus Trejos, Jeffrey Pangilinan, Haruka Okamoto, Katie Cavino, Erqian Na, Angelos Papatheodorou, Tobias Willer, Yu Bai, Jee Hae Kim, Ashique Rafique, Stephen Jaspers, Trevor Stitt, Andrew J. Murphy, George D. Yancopoulos, Jesper Gromada
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/27340da65b5f447ab24e6f3d810b70d9
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spelling	oai:doaj.org-article:27340da65b5f447ab24e6f3d810b70d92021-12-02T15:37:03ZActivin A more prominently regulates muscle mass in primates than does GDF810.1038/ncomms151532041-1723https://doaj.org/article/27340da65b5f447ab24e6f3d810b70d92017-04-01T00:00:00Zhttps://doi.org/10.1038/ncomms15153https://doaj.org/toc/2041-1723Inhibition of GDF8 increases muscle mass in mice, but is less effective in monkeys and humans. Here the authors show that activin A also inhibits muscle hypertrophy and that concomitant inhibition of activin A and GDF8 synergistically increases muscle mass in mice and non-human primates.Esther LatresJason MastaitisWen FuryLawrence MiloscioJesus TrejosJeffrey PangilinanHaruka OkamotoKatie CavinoErqian NaAngelos PapatheodorouTobias WillerYu BaiJee Hae KimAshique RafiqueStephen JaspersTrevor StittAndrew J. MurphyGeorge D. YancopoulosJesper GromadaNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Esther Latres Jason Mastaitis Wen Fury Lawrence Miloscio Jesus Trejos Jeffrey Pangilinan Haruka Okamoto Katie Cavino Erqian Na Angelos Papatheodorou Tobias Willer Yu Bai Jee Hae Kim Ashique Rafique Stephen Jaspers Trevor Stitt Andrew J. Murphy George D. Yancopoulos Jesper Gromada Activin A more prominently regulates muscle mass in primates than does GDF8
description	Inhibition of GDF8 increases muscle mass in mice, but is less effective in monkeys and humans. Here the authors show that activin A also inhibits muscle hypertrophy and that concomitant inhibition of activin A and GDF8 synergistically increases muscle mass in mice and non-human primates.
format	article
author	Esther Latres Jason Mastaitis Wen Fury Lawrence Miloscio Jesus Trejos Jeffrey Pangilinan Haruka Okamoto Katie Cavino Erqian Na Angelos Papatheodorou Tobias Willer Yu Bai Jee Hae Kim Ashique Rafique Stephen Jaspers Trevor Stitt Andrew J. Murphy George D. Yancopoulos Jesper Gromada
author_facet	Esther Latres Jason Mastaitis Wen Fury Lawrence Miloscio Jesus Trejos Jeffrey Pangilinan Haruka Okamoto Katie Cavino Erqian Na Angelos Papatheodorou Tobias Willer Yu Bai Jee Hae Kim Ashique Rafique Stephen Jaspers Trevor Stitt Andrew J. Murphy George D. Yancopoulos Jesper Gromada
author_sort	Esther Latres
title	Activin A more prominently regulates muscle mass in primates than does GDF8
title_short	Activin A more prominently regulates muscle mass in primates than does GDF8
title_full	Activin A more prominently regulates muscle mass in primates than does GDF8
title_fullStr	Activin A more prominently regulates muscle mass in primates than does GDF8
title_full_unstemmed	Activin A more prominently regulates muscle mass in primates than does GDF8
title_sort	activin a more prominently regulates muscle mass in primates than does gdf8
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/27340da65b5f447ab24e6f3d810b70d9
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Activin A more prominently regulates muscle mass in primates than does GDF8

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