Tripartite phase separation of two signal effectors with vesicles priming B cell responsiveness

Tripartite phase separation of two signal effectors with vesicles priming B cell responsiveness

Antibody-mediated immune responses rely on antigen recognition by the B cell antigen receptor (BCR) and SLP65 is a key scaffold protein mediating BCR signaling. Here authors show that effective B cell activation requires tripartite phase separation of SLP65, CIN85, and lipid vesicles.

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Autores principales: Leo E. Wong, Arshiya Bhatt, Philipp S. Erdmann, Zhen Hou, Joachim Maier, Sona Pirkuliyeva, Michael Engelke, Stefan Becker, Jürgen Plitzko, Jürgen Wienands, Christian Griesinger
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Science
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Acceso en línea:https://doaj.org/article/274458207bae4608b1c142b4c80debc7
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https://doaj.org/article/274458207bae4608b1c142b4c80debc7

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