Tripartite phase separation of two signal effectors with vesicles priming B cell responsiveness

Antibody-mediated immune responses rely on antigen recognition by the B cell antigen receptor (BCR) and SLP65 is a key scaffold protein mediating BCR signaling. Here authors show that effective B cell activation requires tripartite phase separation of SLP65, CIN85, and lipid vesicles.

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Autores principales:	Leo E. Wong, Arshiya Bhatt, Philipp S. Erdmann, Zhen Hou, Joachim Maier, Sona Pirkuliyeva, Michael Engelke, Stefan Becker, Jürgen Plitzko, Jürgen Wienands, Christian Griesinger
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/274458207bae4608b1c142b4c80debc7
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spelling	oai:doaj.org-article:274458207bae4608b1c142b4c80debc72021-12-02T15:39:28ZTripartite phase separation of two signal effectors with vesicles priming B cell responsiveness10.1038/s41467-020-14544-12041-1723https://doaj.org/article/274458207bae4608b1c142b4c80debc72020-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-14544-1https://doaj.org/toc/2041-1723Antibody-mediated immune responses rely on antigen recognition by the B cell antigen receptor (BCR) and SLP65 is a key scaffold protein mediating BCR signaling. Here authors show that effective B cell activation requires tripartite phase separation of SLP65, CIN85, and lipid vesicles.Leo E. WongArshiya BhattPhilipp S. ErdmannZhen HouJoachim MaierSona PirkuliyevaMichael EngelkeStefan BeckerJürgen PlitzkoJürgen WienandsChristian GriesingerNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-9 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Leo E. Wong Arshiya Bhatt Philipp S. Erdmann Zhen Hou Joachim Maier Sona Pirkuliyeva Michael Engelke Stefan Becker Jürgen Plitzko Jürgen Wienands Christian Griesinger Tripartite phase separation of two signal effectors with vesicles priming B cell responsiveness
description	Antibody-mediated immune responses rely on antigen recognition by the B cell antigen receptor (BCR) and SLP65 is a key scaffold protein mediating BCR signaling. Here authors show that effective B cell activation requires tripartite phase separation of SLP65, CIN85, and lipid vesicles.
format	article
author	Leo E. Wong Arshiya Bhatt Philipp S. Erdmann Zhen Hou Joachim Maier Sona Pirkuliyeva Michael Engelke Stefan Becker Jürgen Plitzko Jürgen Wienands Christian Griesinger
author_facet	Leo E. Wong Arshiya Bhatt Philipp S. Erdmann Zhen Hou Joachim Maier Sona Pirkuliyeva Michael Engelke Stefan Becker Jürgen Plitzko Jürgen Wienands Christian Griesinger
author_sort	Leo E. Wong
title	Tripartite phase separation of two signal effectors with vesicles priming B cell responsiveness
title_short	Tripartite phase separation of two signal effectors with vesicles priming B cell responsiveness
title_full	Tripartite phase separation of two signal effectors with vesicles priming B cell responsiveness
title_fullStr	Tripartite phase separation of two signal effectors with vesicles priming B cell responsiveness
title_full_unstemmed	Tripartite phase separation of two signal effectors with vesicles priming B cell responsiveness
title_sort	tripartite phase separation of two signal effectors with vesicles priming b cell responsiveness
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/274458207bae4608b1c142b4c80debc7
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Tripartite phase separation of two signal effectors with vesicles priming B cell responsiveness

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