A glutamine sensor that directly activates TORC1

Tanigawa et al. investigate the role of Pib2, a vacuolar protein, in the glutamine-dependent upstream regulation of TORC1 in budding yeast. Their study reveals that Pib2 plays dual roles as a glutamine sensor and a direct TORC1 activator, a finding useful for the community working on TORC1 upstream...

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Autores principales: Mirai Tanigawa, Katsuyoshi Yamamoto, Satoru Nagatoishi, Koji Nagata, Daisuke Noshiro, Nobuo N. Noda, Kouhei Tsumoto, Tatsuya Maeda
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/275a9dd4eb7942b5a85bf66596d18969
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Sumario:Tanigawa et al. investigate the role of Pib2, a vacuolar protein, in the glutamine-dependent upstream regulation of TORC1 in budding yeast. Their study reveals that Pib2 plays dual roles as a glutamine sensor and a direct TORC1 activator, a finding useful for the community working on TORC1 upstream regulation.