A positive feedback loop bi-stably activates fibroblasts

Normal adult tissue fibroblasts can be activated during wound healing, pathologic fibrosis and in cancer stroma, but the regulatory network that controls its dynamics is unknown. Here the authors show that fibroblasts are activated by a positive feedback loop formed by Twist1, Prrx1, and Tenascin-C...

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Bibliographic Details
Main Authors: So-Young Yeo, Keun-Woo Lee, Dongkwan Shin, Sugyun An, Kwang-Hyun Cho, Seok-Hyung Kim
Format: article
Language:EN
Published: Nature Portfolio 2018
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Online Access:https://doaj.org/article/2764ab54e1634e5dbd32e110b5ef0b15
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