Dual blockade of CD47 and HER2 eliminates radioresistant breast cancer cells
The emergence of tumour adaptive radioresistance can limit the success of radiation therapy and immunotherapy in breast cancer. In this study, the authors demonstrate that CD47 and HER2 are coordinating in tumor response to radiation and that co-blockage of both receptors can eliminate radiorestista...
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Nature Portfolio
2020
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oai:doaj.org-article:278b23d810204e89b5b3f18e5d760fef2021-12-02T18:02:16ZDual blockade of CD47 and HER2 eliminates radioresistant breast cancer cells10.1038/s41467-020-18245-72041-1723https://doaj.org/article/278b23d810204e89b5b3f18e5d760fef2020-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-18245-7https://doaj.org/toc/2041-1723The emergence of tumour adaptive radioresistance can limit the success of radiation therapy and immunotherapy in breast cancer. In this study, the authors demonstrate that CD47 and HER2 are coordinating in tumor response to radiation and that co-blockage of both receptors can eliminate radiorestistant breast cancer cells.Demet Candas-GreenBowen XieJie HuangMing FanAijun WangCheikh MenaaYanhong ZhangLu ZhangDi JingSoheila AzghadiWeibing ZhouLin LiuNian JiangTao LiTianyi GaoColleen SweeneyRulong ShenTzu-yin LinChong-xian PanOmer M. OzpiskinGayle WoloschakDavid J. GrdinaAndrew T. VaughanJi Ming WangShuli XiaArta M. MonjazebWilliam J. MurphyLun-Quan SunHong-Wu ChenKit S. LamRalph R. WeichselbaumJian Jian LiNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-15 (2020) |
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DOAJ |
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EN |
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Science Q Demet Candas-Green Bowen Xie Jie Huang Ming Fan Aijun Wang Cheikh Menaa Yanhong Zhang Lu Zhang Di Jing Soheila Azghadi Weibing Zhou Lin Liu Nian Jiang Tao Li Tianyi Gao Colleen Sweeney Rulong Shen Tzu-yin Lin Chong-xian Pan Omer M. Ozpiskin Gayle Woloschak David J. Grdina Andrew T. Vaughan Ji Ming Wang Shuli Xia Arta M. Monjazeb William J. Murphy Lun-Quan Sun Hong-Wu Chen Kit S. Lam Ralph R. Weichselbaum Jian Jian Li Dual blockade of CD47 and HER2 eliminates radioresistant breast cancer cells |
| description |
The emergence of tumour adaptive radioresistance can limit the success of radiation therapy and immunotherapy in breast cancer. In this study, the authors demonstrate that CD47 and HER2 are coordinating in tumor response to radiation and that co-blockage of both receptors can eliminate radiorestistant breast cancer cells. |
| format |
article |
| author |
Demet Candas-Green Bowen Xie Jie Huang Ming Fan Aijun Wang Cheikh Menaa Yanhong Zhang Lu Zhang Di Jing Soheila Azghadi Weibing Zhou Lin Liu Nian Jiang Tao Li Tianyi Gao Colleen Sweeney Rulong Shen Tzu-yin Lin Chong-xian Pan Omer M. Ozpiskin Gayle Woloschak David J. Grdina Andrew T. Vaughan Ji Ming Wang Shuli Xia Arta M. Monjazeb William J. Murphy Lun-Quan Sun Hong-Wu Chen Kit S. Lam Ralph R. Weichselbaum Jian Jian Li |
| author_facet |
Demet Candas-Green Bowen Xie Jie Huang Ming Fan Aijun Wang Cheikh Menaa Yanhong Zhang Lu Zhang Di Jing Soheila Azghadi Weibing Zhou Lin Liu Nian Jiang Tao Li Tianyi Gao Colleen Sweeney Rulong Shen Tzu-yin Lin Chong-xian Pan Omer M. Ozpiskin Gayle Woloschak David J. Grdina Andrew T. Vaughan Ji Ming Wang Shuli Xia Arta M. Monjazeb William J. Murphy Lun-Quan Sun Hong-Wu Chen Kit S. Lam Ralph R. Weichselbaum Jian Jian Li |
| author_sort |
Demet Candas-Green |
| title |
Dual blockade of CD47 and HER2 eliminates radioresistant breast cancer cells |
| title_short |
Dual blockade of CD47 and HER2 eliminates radioresistant breast cancer cells |
| title_full |
Dual blockade of CD47 and HER2 eliminates radioresistant breast cancer cells |
| title_fullStr |
Dual blockade of CD47 and HER2 eliminates radioresistant breast cancer cells |
| title_full_unstemmed |
Dual blockade of CD47 and HER2 eliminates radioresistant breast cancer cells |
| title_sort |
dual blockade of cd47 and her2 eliminates radioresistant breast cancer cells |
| publisher |
Nature Portfolio |
| publishDate |
2020 |
| url |
https://doaj.org/article/278b23d810204e89b5b3f18e5d760fef |
| work_keys_str_mv |
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