Complement C3 mediates early hippocampal neurodegeneration and memory impairment in experimental multiple sclerosis

Complement C3 mediates early hippocampal neurodegeneration and memory impairment in experimental multiple sclerosis

Memory impairment is one of the disabling manifestations of multiple sclerosis (MS) possibly present from the early stages of the disease and for which there is no specific treatment. Hippocampal synaptic dysfunction and dendritic loss, associated with microglial activation, can underlie memory defi...

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Auteurs principaux: Julien Bourel, Vincent Planche, Nadège Dubourdieu, Aymeric Oliveira, Alexandra Séré, Eva-Gunnel Ducourneau, Marion Tible, Marlène Maitre, Thierry Lesté-Lasserre, Agnes Nadjar, Aline Desmedt, Philippe Ciofi, Stéphane H. Oliet, Aude Panatier, Thomas Tourdias
Format: article
Langue:EN
Publié: Elsevier 2021
Sujets:
Multiple sclerosis
Memory deficit
hippocampus
Neurodegeneration
Complement
Microglia
Neurosciences. Biological psychiatry. Neuropsychiatry
RC321-571
Accès en ligne:https://doaj.org/article/2795f1f4556d468198d33235f37e06f4
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https://doaj.org/article/2795f1f4556d468198d33235f37e06f4

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