Lysosomal recruitment of TSC2 is a universal response to cellular stress

In response to amino acid and growth factor removal the TSC1/2 complex translocates to the lysosome to inactivate mTOR and inhibit cell growth. Here, the authors have shown that other cellular stresses also trigger this translocation to the lysosome suggesting that this is a universal mechanism in t...

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Autores principales: Constantinos Demetriades, Monika Plescher, Aurelio A. Teleman
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
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Acceso en línea:https://doaj.org/article/27c04ce164a1440f867e94660882754d
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