Lysosomal recruitment of TSC2 is a universal response to cellular stress

In response to amino acid and growth factor removal the TSC1/2 complex translocates to the lysosome to inactivate mTOR and inhibit cell growth. Here, the authors have shown that other cellular stresses also trigger this translocation to the lysosome suggesting that this is a universal mechanism in t...

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Autores principales:	Constantinos Demetriades, Monika Plescher, Aurelio A. Teleman
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/27c04ce164a1440f867e94660882754d
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id	oai:doaj.org-article:27c04ce164a1440f867e94660882754d
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spelling	oai:doaj.org-article:27c04ce164a1440f867e94660882754d2021-12-02T17:31:47ZLysosomal recruitment of TSC2 is a universal response to cellular stress10.1038/ncomms106622041-1723https://doaj.org/article/27c04ce164a1440f867e94660882754d2016-02-01T00:00:00Zhttps://doi.org/10.1038/ncomms10662https://doaj.org/toc/2041-1723In response to amino acid and growth factor removal the TSC1/2 complex translocates to the lysosome to inactivate mTOR and inhibit cell growth. Here, the authors have shown that other cellular stresses also trigger this translocation to the lysosome suggesting that this is a universal mechanism in the stress response.Constantinos DemetriadesMonika PlescherAurelio A. TelemanNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Constantinos Demetriades Monika Plescher Aurelio A. Teleman Lysosomal recruitment of TSC2 is a universal response to cellular stress
description	In response to amino acid and growth factor removal the TSC1/2 complex translocates to the lysosome to inactivate mTOR and inhibit cell growth. Here, the authors have shown that other cellular stresses also trigger this translocation to the lysosome suggesting that this is a universal mechanism in the stress response.
format	article
author	Constantinos Demetriades Monika Plescher Aurelio A. Teleman
author_facet	Constantinos Demetriades Monika Plescher Aurelio A. Teleman
author_sort	Constantinos Demetriades
title	Lysosomal recruitment of TSC2 is a universal response to cellular stress
title_short	Lysosomal recruitment of TSC2 is a universal response to cellular stress
title_full	Lysosomal recruitment of TSC2 is a universal response to cellular stress
title_fullStr	Lysosomal recruitment of TSC2 is a universal response to cellular stress
title_full_unstemmed	Lysosomal recruitment of TSC2 is a universal response to cellular stress
title_sort	lysosomal recruitment of tsc2 is a universal response to cellular stress
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/27c04ce164a1440f867e94660882754d
work_keys_str_mv	AT constantinosdemetriades lysosomalrecruitmentoftsc2isauniversalresponsetocellularstress AT monikaplescher lysosomalrecruitmentoftsc2isauniversalresponsetocellularstress AT aurelioateleman lysosomalrecruitmentoftsc2isauniversalresponsetocellularstress
_version_	1718380478704123904

Lysosomal recruitment of TSC2 is a universal response to cellular stress

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