Mitochondrial ATP transporter depletion protects mice against liver steatosis and insulin resistance
Adenine nucleotide translocase (ANT) 2 promotes ADP/ATP exchange across the mitochondrial inner membrane. Choet al. show that liver specific Ant2 deletion increases uncoupled respiration and protects mice against fatty liver and obesity-induced insulin resistance.
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Main Authors: | Joonseok Cho, Yujian Zhang, Shi-Young Park, Anna-Maria Joseph, Chul Han, Hyo-Jin Park, Srilaxmi Kalavalapalli, Sung-Kook Chun, Drake Morgan, Jae-Sung Kim, Shinichi Someya, Clayton E. Mathews, Young Jae Lee, Stephanie E. Wohlgemuth, Nishanth E. Sunny, Hui-Young Lee, Cheol Soo Choi, Takayuki Shiratsuchi, S. Paul Oh, Naohiro Terada |
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Format: | article |
Language: | EN |
Published: |
Nature Portfolio
2017
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Subjects: | |
Online Access: | https://doaj.org/article/27c33827aff94d8b88865b49e3ea384d |
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