A genetic screen in macrophages identifies new regulators of IFNγ-inducible MHCII that contribute to T cell activation

A genetic screen in macrophages identifies new regulators of IFNγ-inducible MHCII that contribute to T cell activation

Cytokine-mediated activation of host immunity is central to the control of pathogens. Interferon-gamma (IFNγ) is a key cytokine in protective immunity that induces major histocompatibility complex class II molecules (MHCII) to amplify CD4+ T cell activation and effector function. Despite its central...

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Autores principales: Michael C Kiritsy, Laurisa M Ankley, Justin Trombley, Gabrielle P Huizinga, Audrey E Lord, Pontus Orning, Roland Elling, Katherine A Fitzgerald, Andrew J Olive
Formato: article
Lenguaje:EN
Publicado: eLife Sciences Publications Ltd 2021
Materias:
IFN-gamma
MHCII expression
CD4+ T cell activation
macrophages
Medicine
R
Science
Q
Biology (General)
QH301-705.5
Acceso en línea:https://doaj.org/article/27cb52ae4b22483f922ca3e06412e9cd
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https://doaj.org/article/27cb52ae4b22483f922ca3e06412e9cd

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