PALB2 chromatin recruitment restores homologous recombination in BRCA1-deficient cells depleted of 53BP1

Although loss of BRCA1 leads to defects in DNA double-strand break repair by homologous recombination (HR) and renders cells hypersensitive to PARP inhibitors, resistance to the drugs can arise. Here the authors reveal that PALB2 chromatin recruitment restores HR in BRCA1-deficient cells depleted of...

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Autores principales:	Rimma Belotserkovskaya, Elisenda Raga Gil, Nicola Lawrence, Richard Butler, Gillian Clifford, Marcus D. Wilson, Stephen P. Jackson
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/27e5c324517044009192fd0e36311b88
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spelling	oai:doaj.org-article:27e5c324517044009192fd0e36311b882021-12-02T17:31:56ZPALB2 chromatin recruitment restores homologous recombination in BRCA1-deficient cells depleted of 53BP110.1038/s41467-020-14563-y2041-1723https://doaj.org/article/27e5c324517044009192fd0e36311b882020-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-14563-yhttps://doaj.org/toc/2041-1723Although loss of BRCA1 leads to defects in DNA double-strand break repair by homologous recombination (HR) and renders cells hypersensitive to PARP inhibitors, resistance to the drugs can arise. Here the authors reveal that PALB2 chromatin recruitment restores HR in BRCA1-deficient cells depleted of 53BP1.Rimma BelotserkovskayaElisenda Raga GilNicola LawrenceRichard ButlerGillian CliffordMarcus D. WilsonStephen P. JacksonNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Rimma Belotserkovskaya Elisenda Raga Gil Nicola Lawrence Richard Butler Gillian Clifford Marcus D. Wilson Stephen P. Jackson PALB2 chromatin recruitment restores homologous recombination in BRCA1-deficient cells depleted of 53BP1
description	Although loss of BRCA1 leads to defects in DNA double-strand break repair by homologous recombination (HR) and renders cells hypersensitive to PARP inhibitors, resistance to the drugs can arise. Here the authors reveal that PALB2 chromatin recruitment restores HR in BRCA1-deficient cells depleted of 53BP1.
format	article
author	Rimma Belotserkovskaya Elisenda Raga Gil Nicola Lawrence Richard Butler Gillian Clifford Marcus D. Wilson Stephen P. Jackson
author_facet	Rimma Belotserkovskaya Elisenda Raga Gil Nicola Lawrence Richard Butler Gillian Clifford Marcus D. Wilson Stephen P. Jackson
author_sort	Rimma Belotserkovskaya
title	PALB2 chromatin recruitment restores homologous recombination in BRCA1-deficient cells depleted of 53BP1
title_short	PALB2 chromatin recruitment restores homologous recombination in BRCA1-deficient cells depleted of 53BP1
title_full	PALB2 chromatin recruitment restores homologous recombination in BRCA1-deficient cells depleted of 53BP1
title_fullStr	PALB2 chromatin recruitment restores homologous recombination in BRCA1-deficient cells depleted of 53BP1
title_full_unstemmed	PALB2 chromatin recruitment restores homologous recombination in BRCA1-deficient cells depleted of 53BP1
title_sort	palb2 chromatin recruitment restores homologous recombination in brca1-deficient cells depleted of 53bp1
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/27e5c324517044009192fd0e36311b88
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PALB2 chromatin recruitment restores homologous recombination in BRCA1-deficient cells depleted of 53BP1

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