Mapping tenascin-C interaction with toll-like receptor 4 reveals a new subset of endogenous inflammatory triggers

Although detection of pathogens by pattern recognition receptors is increasingly well defined, recognition of endogenous triggers remains poorly understood. By examining the interface between tenascin-C and TLR4, the authors identify a molecular code that identifies endogenous proteins as inflammato...

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Autores principales: Lorena Zuliani-Alvarez, Anna M. Marzeda, Claire Deligne, Anja Schwenzer, Fiona E. McCann, Brian D. Marsden, Anna M. Piccinini, Kim S. Midwood
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Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/280b5571ad664b09ab67b12a008edf59
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spelling oai:doaj.org-article:280b5571ad664b09ab67b12a008edf592021-12-02T14:41:19ZMapping tenascin-C interaction with toll-like receptor 4 reveals a new subset of endogenous inflammatory triggers10.1038/s41467-017-01718-72041-1723https://doaj.org/article/280b5571ad664b09ab67b12a008edf592017-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01718-7https://doaj.org/toc/2041-1723Although detection of pathogens by pattern recognition receptors is increasingly well defined, recognition of endogenous triggers remains poorly understood. By examining the interface between tenascin-C and TLR4, the authors identify a molecular code that identifies endogenous proteins as inflammatory stimuli.Lorena Zuliani-AlvarezAnna M. MarzedaClaire DeligneAnja SchwenzerFiona E. McCannBrian D. MarsdenAnna M. PiccininiKim S. MidwoodNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Lorena Zuliani-Alvarez
Anna M. Marzeda
Claire Deligne
Anja Schwenzer
Fiona E. McCann
Brian D. Marsden
Anna M. Piccinini
Kim S. Midwood
Mapping tenascin-C interaction with toll-like receptor 4 reveals a new subset of endogenous inflammatory triggers
description Although detection of pathogens by pattern recognition receptors is increasingly well defined, recognition of endogenous triggers remains poorly understood. By examining the interface between tenascin-C and TLR4, the authors identify a molecular code that identifies endogenous proteins as inflammatory stimuli.
format article
author Lorena Zuliani-Alvarez
Anna M. Marzeda
Claire Deligne
Anja Schwenzer
Fiona E. McCann
Brian D. Marsden
Anna M. Piccinini
Kim S. Midwood
author_facet Lorena Zuliani-Alvarez
Anna M. Marzeda
Claire Deligne
Anja Schwenzer
Fiona E. McCann
Brian D. Marsden
Anna M. Piccinini
Kim S. Midwood
author_sort Lorena Zuliani-Alvarez
title Mapping tenascin-C interaction with toll-like receptor 4 reveals a new subset of endogenous inflammatory triggers
title_short Mapping tenascin-C interaction with toll-like receptor 4 reveals a new subset of endogenous inflammatory triggers
title_full Mapping tenascin-C interaction with toll-like receptor 4 reveals a new subset of endogenous inflammatory triggers
title_fullStr Mapping tenascin-C interaction with toll-like receptor 4 reveals a new subset of endogenous inflammatory triggers
title_full_unstemmed Mapping tenascin-C interaction with toll-like receptor 4 reveals a new subset of endogenous inflammatory triggers
title_sort mapping tenascin-c interaction with toll-like receptor 4 reveals a new subset of endogenous inflammatory triggers
publisher Nature Portfolio
publishDate 2017
url https://doaj.org/article/280b5571ad664b09ab67b12a008edf59
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