Mapping tenascin-C interaction with toll-like receptor 4 reveals a new subset of endogenous inflammatory triggers
Although detection of pathogens by pattern recognition receptors is increasingly well defined, recognition of endogenous triggers remains poorly understood. By examining the interface between tenascin-C and TLR4, the authors identify a molecular code that identifies endogenous proteins as inflammato...
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Nature Portfolio
2017
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oai:doaj.org-article:280b5571ad664b09ab67b12a008edf592021-12-02T14:41:19ZMapping tenascin-C interaction with toll-like receptor 4 reveals a new subset of endogenous inflammatory triggers10.1038/s41467-017-01718-72041-1723https://doaj.org/article/280b5571ad664b09ab67b12a008edf592017-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01718-7https://doaj.org/toc/2041-1723Although detection of pathogens by pattern recognition receptors is increasingly well defined, recognition of endogenous triggers remains poorly understood. By examining the interface between tenascin-C and TLR4, the authors identify a molecular code that identifies endogenous proteins as inflammatory stimuli.Lorena Zuliani-AlvarezAnna M. MarzedaClaire DeligneAnja SchwenzerFiona E. McCannBrian D. MarsdenAnna M. PiccininiKim S. MidwoodNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-14 (2017) |
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Science Q Lorena Zuliani-Alvarez Anna M. Marzeda Claire Deligne Anja Schwenzer Fiona E. McCann Brian D. Marsden Anna M. Piccinini Kim S. Midwood Mapping tenascin-C interaction with toll-like receptor 4 reveals a new subset of endogenous inflammatory triggers |
description |
Although detection of pathogens by pattern recognition receptors is increasingly well defined, recognition of endogenous triggers remains poorly understood. By examining the interface between tenascin-C and TLR4, the authors identify a molecular code that identifies endogenous proteins as inflammatory stimuli. |
format |
article |
author |
Lorena Zuliani-Alvarez Anna M. Marzeda Claire Deligne Anja Schwenzer Fiona E. McCann Brian D. Marsden Anna M. Piccinini Kim S. Midwood |
author_facet |
Lorena Zuliani-Alvarez Anna M. Marzeda Claire Deligne Anja Schwenzer Fiona E. McCann Brian D. Marsden Anna M. Piccinini Kim S. Midwood |
author_sort |
Lorena Zuliani-Alvarez |
title |
Mapping tenascin-C interaction with toll-like receptor 4 reveals a new subset of endogenous inflammatory triggers |
title_short |
Mapping tenascin-C interaction with toll-like receptor 4 reveals a new subset of endogenous inflammatory triggers |
title_full |
Mapping tenascin-C interaction with toll-like receptor 4 reveals a new subset of endogenous inflammatory triggers |
title_fullStr |
Mapping tenascin-C interaction with toll-like receptor 4 reveals a new subset of endogenous inflammatory triggers |
title_full_unstemmed |
Mapping tenascin-C interaction with toll-like receptor 4 reveals a new subset of endogenous inflammatory triggers |
title_sort |
mapping tenascin-c interaction with toll-like receptor 4 reveals a new subset of endogenous inflammatory triggers |
publisher |
Nature Portfolio |
publishDate |
2017 |
url |
https://doaj.org/article/280b5571ad664b09ab67b12a008edf59 |
work_keys_str_mv |
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_version_ |
1718389919416582144 |