Regenerative capacity of old muscle stem cells declines without significant accumulation of DNA damage.

The performance of adult stem cells is crucial for tissue homeostasis but their regenerative capacity declines with age, leading to failure of multiple organs. In skeletal muscle this failure is manifested by the loss of functional tissue, the accumulation of fibrosis, and reduced satellite cell-med...

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Autores principales: Wendy Cousin, Michelle Liane Ho, Rajiv Desai, Andrea Tham, Robert Yuzen Chen, Sunny Kung, Christian Elabd, Irina M Conboy
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2013
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Acceso en línea:https://doaj.org/article/280f719abec645d885160bdaabdcb7e6
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