E-cadherin focuses protrusion formation at the front of migrating cells by impeding actin flow

The arrival of migratory cells at their targets relies on following precise routes within tissues. Here the authors demonstrate that the cell adhesion molecule E-cadherin can control the path of cell migration by confining the site where bleb-type protrusions form within the cell front.

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Autores principales:	Cecilia Grimaldi, Isabel Schumacher, Aleix Boquet-Pujadas, Katsiaryna Tarbashevich, Bart Eduard Vos, Jan Bandemer, Jan Schick, Anne Aalto, Jean-Christophe Olivo-Marin, Timo Betz, Erez Raz
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/28360082faba432bb37092c10016f635
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spelling	oai:doaj.org-article:28360082faba432bb37092c10016f6352021-12-02T15:37:19ZE-cadherin focuses protrusion formation at the front of migrating cells by impeding actin flow10.1038/s41467-020-19114-z2041-1723https://doaj.org/article/28360082faba432bb37092c10016f6352020-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-19114-zhttps://doaj.org/toc/2041-1723The arrival of migratory cells at their targets relies on following precise routes within tissues. Here the authors demonstrate that the cell adhesion molecule E-cadherin can control the path of cell migration by confining the site where bleb-type protrusions form within the cell front.Cecilia GrimaldiIsabel SchumacherAleix Boquet-PujadasKatsiaryna TarbashevichBart Eduard VosJan BandemerJan SchickAnne AaltoJean-Christophe Olivo-MarinTimo BetzErez RazNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Cecilia Grimaldi Isabel Schumacher Aleix Boquet-Pujadas Katsiaryna Tarbashevich Bart Eduard Vos Jan Bandemer Jan Schick Anne Aalto Jean-Christophe Olivo-Marin Timo Betz Erez Raz E-cadherin focuses protrusion formation at the front of migrating cells by impeding actin flow
description	The arrival of migratory cells at their targets relies on following precise routes within tissues. Here the authors demonstrate that the cell adhesion molecule E-cadherin can control the path of cell migration by confining the site where bleb-type protrusions form within the cell front.
format	article
author	Cecilia Grimaldi Isabel Schumacher Aleix Boquet-Pujadas Katsiaryna Tarbashevich Bart Eduard Vos Jan Bandemer Jan Schick Anne Aalto Jean-Christophe Olivo-Marin Timo Betz Erez Raz
author_facet	Cecilia Grimaldi Isabel Schumacher Aleix Boquet-Pujadas Katsiaryna Tarbashevich Bart Eduard Vos Jan Bandemer Jan Schick Anne Aalto Jean-Christophe Olivo-Marin Timo Betz Erez Raz
author_sort	Cecilia Grimaldi
title	E-cadherin focuses protrusion formation at the front of migrating cells by impeding actin flow
title_short	E-cadherin focuses protrusion formation at the front of migrating cells by impeding actin flow
title_full	E-cadherin focuses protrusion formation at the front of migrating cells by impeding actin flow
title_fullStr	E-cadherin focuses protrusion formation at the front of migrating cells by impeding actin flow
title_full_unstemmed	E-cadherin focuses protrusion formation at the front of migrating cells by impeding actin flow
title_sort	e-cadherin focuses protrusion formation at the front of migrating cells by impeding actin flow
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/28360082faba432bb37092c10016f635
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E-cadherin focuses protrusion formation at the front of migrating cells by impeding actin flow

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