Chemokine CCL2 prevents opioid-induced inhibition of nociceptive synaptic transmission in spinal cord dorsal horn

Abstract Background Opioid analgesics remain widely used for pain treatment despite the related serious side effects. Some of those, such as opioid tolerance and opioid-induced hyperalgesia may be at least partially due to modulation of opioid receptors (OR) function at nociceptive synapses in the s...

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Bibliographic Details
Main Authors: Mario Heles, Petra Mrozkova, Dominika Sulcova, Pavel Adamek, Diana Spicarova, Jiri Palecek
Format: article
Language:EN
Published: BMC 2021
Subjects:
MOR
Online Access:https://doaj.org/article/283da2c846314e67b4b0e0c8da04c39f
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