Fatty acylation enhances the cellular internalization and cytosolic distribution of a cystine-knot peptide

Summary: Delivering peptides into cells could open up possibilities for targeting intracellular proteins. Although fatty acylation of peptide therapeutics improves their systemic half-life, it remains unclear how it influences their cellular uptake. Here, we demonstrate that a fatty acylated peptide...

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Auteurs principaux: Xinxin Gao, Ann De Mazière, Rhiannon Beard, Judith Klumperman, Rami N. Hannoush
Format: article
Langue:EN
Publié: Elsevier 2021
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Q
Accès en ligne:https://doaj.org/article/287ac2a1e17845f6811e652189cbfe08
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