Fatty acylation enhances the cellular internalization and cytosolic distribution of a cystine-knot peptide
Summary: Delivering peptides into cells could open up possibilities for targeting intracellular proteins. Although fatty acylation of peptide therapeutics improves their systemic half-life, it remains unclear how it influences their cellular uptake. Here, we demonstrate that a fatty acylated peptide...
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Autores principales: | Xinxin Gao, Ann De Mazière, Rhiannon Beard, Judith Klumperman, Rami N. Hannoush |
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Formato: | article |
Lenguaje: | EN |
Publicado: |
Elsevier
2021
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Materias: | |
Acceso en línea: | https://doaj.org/article/287ac2a1e17845f6811e652189cbfe08 |
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