FANCM limits ALT activity by restricting telomeric replication stress induced by deregulated BLM and R-loops

In cancer cells, telomeres can be elongated through homology directed-repair pathways in a process known as Alternative Lengthening of Telomeres (ALT). Here, the authors reveal that FANCM regulates ALT activity and ALT cell proliferation by limiting the activity of uncontrolled BLM and telomeric R-l...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Bruno Silva, Richard Pentz, Ana Margarida Figueira, Rajika Arora, Yong Woo Lee, Charlotte Hodson, Harry Wischnewski, Andrew J. Deans, Claus M. Azzalin
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/288a7c4d17534c13992012134d9710a4
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:288a7c4d17534c13992012134d9710a4
record_format	dspace
spelling	oai:doaj.org-article:288a7c4d17534c13992012134d9710a42021-12-02T14:38:44ZFANCM limits ALT activity by restricting telomeric replication stress induced by deregulated BLM and R-loops10.1038/s41467-019-10179-z2041-1723https://doaj.org/article/288a7c4d17534c13992012134d9710a42019-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10179-zhttps://doaj.org/toc/2041-1723In cancer cells, telomeres can be elongated through homology directed-repair pathways in a process known as Alternative Lengthening of Telomeres (ALT). Here, the authors reveal that FANCM regulates ALT activity and ALT cell proliferation by limiting the activity of uncontrolled BLM and telomeric R-loops.Bruno SilvaRichard PentzAna Margarida FigueiraRajika AroraYong Woo LeeCharlotte HodsonHarry WischnewskiAndrew J. DeansClaus M. AzzalinNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Bruno Silva Richard Pentz Ana Margarida Figueira Rajika Arora Yong Woo Lee Charlotte Hodson Harry Wischnewski Andrew J. Deans Claus M. Azzalin FANCM limits ALT activity by restricting telomeric replication stress induced by deregulated BLM and R-loops
description	In cancer cells, telomeres can be elongated through homology directed-repair pathways in a process known as Alternative Lengthening of Telomeres (ALT). Here, the authors reveal that FANCM regulates ALT activity and ALT cell proliferation by limiting the activity of uncontrolled BLM and telomeric R-loops.
format	article
author	Bruno Silva Richard Pentz Ana Margarida Figueira Rajika Arora Yong Woo Lee Charlotte Hodson Harry Wischnewski Andrew J. Deans Claus M. Azzalin
author_facet	Bruno Silva Richard Pentz Ana Margarida Figueira Rajika Arora Yong Woo Lee Charlotte Hodson Harry Wischnewski Andrew J. Deans Claus M. Azzalin
author_sort	Bruno Silva
title	FANCM limits ALT activity by restricting telomeric replication stress induced by deregulated BLM and R-loops
title_short	FANCM limits ALT activity by restricting telomeric replication stress induced by deregulated BLM and R-loops
title_full	FANCM limits ALT activity by restricting telomeric replication stress induced by deregulated BLM and R-loops
title_fullStr	FANCM limits ALT activity by restricting telomeric replication stress induced by deregulated BLM and R-loops
title_full_unstemmed	FANCM limits ALT activity by restricting telomeric replication stress induced by deregulated BLM and R-loops
title_sort	fancm limits alt activity by restricting telomeric replication stress induced by deregulated blm and r-loops
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/288a7c4d17534c13992012134d9710a4
work_keys_str_mv	AT brunosilva fancmlimitsaltactivitybyrestrictingtelomericreplicationstressinducedbyderegulatedblmandrloops AT richardpentz fancmlimitsaltactivitybyrestrictingtelomericreplicationstressinducedbyderegulatedblmandrloops AT anamargaridafigueira fancmlimitsaltactivitybyrestrictingtelomericreplicationstressinducedbyderegulatedblmandrloops AT rajikaarora fancmlimitsaltactivitybyrestrictingtelomericreplicationstressinducedbyderegulatedblmandrloops AT yongwoolee fancmlimitsaltactivitybyrestrictingtelomericreplicationstressinducedbyderegulatedblmandrloops AT charlottehodson fancmlimitsaltactivitybyrestrictingtelomericreplicationstressinducedbyderegulatedblmandrloops AT harrywischnewski fancmlimitsaltactivitybyrestrictingtelomericreplicationstressinducedbyderegulatedblmandrloops AT andrewjdeans fancmlimitsaltactivitybyrestrictingtelomericreplicationstressinducedbyderegulatedblmandrloops AT clausmazzalin fancmlimitsaltactivitybyrestrictingtelomericreplicationstressinducedbyderegulatedblmandrloops
_version_	1718390881422147584

FANCM limits ALT activity by restricting telomeric replication stress induced by deregulated BLM and R-loops

Ejemplares similares