Does the Presence of Cytokeratin Positive Individual Tumor Cells (N0(I+)) in Sentinel Lymph Nodes Affect Clinical Outcomes in Breast Cancer Patients Treated with Accelerated Partial Breast Irradiation

Jamie Smith,1 Charles Leonard,1 Dennis L Carter,2 Shannon Tole1 1Rocky Mountain Cancer Centers Littleton, Denver, CO, USA; 2Rocky Mountain Cancer Centers Aurora, Denver, Co, USACorrespondence: Jamie SmithRocky Mountain Cancer Centers Littleton, 790 Fillmore St., Denver, Co, 80206, USATel +1 303-304-...

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Autores principales:	Smith J, Leonard C, Carter DL, Tole S
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	breast sentinel nodes breast conservation therapy Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/289394328a2846559a0bb8f9193e9fa5
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spelling	oai:doaj.org-article:289394328a2846559a0bb8f9193e9fa52021-12-02T19:02:31ZDoes the Presence of Cytokeratin Positive Individual Tumor Cells (N0(I+)) in Sentinel Lymph Nodes Affect Clinical Outcomes in Breast Cancer Patients Treated with Accelerated Partial Breast Irradiation1179-1314https://doaj.org/article/289394328a2846559a0bb8f9193e9fa52021-08-01T00:00:00Zhttps://www.dovepress.com/does-the-presence-of-cytokeratin-positive-individual-tumor-cells-n0i-i-peer-reviewed-fulltext-article-BCTThttps://doaj.org/toc/1179-1314Jamie Smith,1 Charles Leonard,1 Dennis L Carter,2 Shannon Tole1 1Rocky Mountain Cancer Centers Littleton, Denver, CO, USA; 2Rocky Mountain Cancer Centers Aurora, Denver, Co, USACorrespondence: Jamie SmithRocky Mountain Cancer Centers Littleton, 790 Fillmore St., Denver, Co, 80206, USATel +1 303-304-1187Email 1007jamiesmith@gmail.comPurpose: To report a primary objective clinical outcome of ipsilateral breast cancer recurrence following accelerated partial breast irradiation (APBI) with N0(i+) (single tumor cells or clusters < 2mm) in sentinel lymph nodes. The secondary objective was to observe any incidence of ipsilateral breast failure.Patients and Methods: Between March 2004 and April 2016, a total of 747 patients were enrolled in one of two APBI (Accelerated Partial Breast Irradiation) breast protocols (Phase II NCT01185145 and Phase III NCT01185132). Nineteen patients with N0(i+) disease were treated between February 2005 and December 2015. Patient eligibility included a primary invasive or DCIS tumor size < 3 cm, N0(i+) disease, and margin width of > 2 mm. All enrolled patients presented in this report had sentinel lymph node examinations. Clinical outcomes of ipsilateral breast, axillary and combined regional (breast or axillary) recurrences were analyzed.Results: Median follow-up for all patients was 5 years (1– 8 years). No patient experienced either ipsilateral breast or axillary recurrence.Conclusion: There has been scarce information/reporting of the treatment of patients with cytokeratin positive individual tumor cells N0(i+) with APBI. The authors have presented data which suggest that the successful outcomes of these patients might warrant further study.Keywords: breast sentinel nodes, breast conservation therapySmith JLeonard CCarter DLTole SDove Medical Pressarticlebreast sentinel nodesbreast conservation therapyNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENBreast Cancer: Targets and Therapy, Vol Volume 13, Pp 513-517 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	breast sentinel nodes breast conservation therapy Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	breast sentinel nodes breast conservation therapy Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Smith J Leonard C Carter DL Tole S Does the Presence of Cytokeratin Positive Individual Tumor Cells (N0(I+)) in Sentinel Lymph Nodes Affect Clinical Outcomes in Breast Cancer Patients Treated with Accelerated Partial Breast Irradiation
description	Jamie Smith,1 Charles Leonard,1 Dennis L Carter,2 Shannon Tole1 1Rocky Mountain Cancer Centers Littleton, Denver, CO, USA; 2Rocky Mountain Cancer Centers Aurora, Denver, Co, USACorrespondence: Jamie SmithRocky Mountain Cancer Centers Littleton, 790 Fillmore St., Denver, Co, 80206, USATel +1 303-304-1187Email 1007jamiesmith@gmail.comPurpose: To report a primary objective clinical outcome of ipsilateral breast cancer recurrence following accelerated partial breast irradiation (APBI) with N0(i+) (single tumor cells or clusters < 2mm) in sentinel lymph nodes. The secondary objective was to observe any incidence of ipsilateral breast failure.Patients and Methods: Between March 2004 and April 2016, a total of 747 patients were enrolled in one of two APBI (Accelerated Partial Breast Irradiation) breast protocols (Phase II NCT01185145 and Phase III NCT01185132). Nineteen patients with N0(i+) disease were treated between February 2005 and December 2015. Patient eligibility included a primary invasive or DCIS tumor size < 3 cm, N0(i+) disease, and margin width of > 2 mm. All enrolled patients presented in this report had sentinel lymph node examinations. Clinical outcomes of ipsilateral breast, axillary and combined regional (breast or axillary) recurrences were analyzed.Results: Median follow-up for all patients was 5 years (1– 8 years). No patient experienced either ipsilateral breast or axillary recurrence.Conclusion: There has been scarce information/reporting of the treatment of patients with cytokeratin positive individual tumor cells N0(i+) with APBI. The authors have presented data which suggest that the successful outcomes of these patients might warrant further study.Keywords: breast sentinel nodes, breast conservation therapy
format	article
author	Smith J Leonard C Carter DL Tole S
author_facet	Smith J Leonard C Carter DL Tole S
author_sort	Smith J
title	Does the Presence of Cytokeratin Positive Individual Tumor Cells (N0(I+)) in Sentinel Lymph Nodes Affect Clinical Outcomes in Breast Cancer Patients Treated with Accelerated Partial Breast Irradiation
title_short	Does the Presence of Cytokeratin Positive Individual Tumor Cells (N0(I+)) in Sentinel Lymph Nodes Affect Clinical Outcomes in Breast Cancer Patients Treated with Accelerated Partial Breast Irradiation
title_full	Does the Presence of Cytokeratin Positive Individual Tumor Cells (N0(I+)) in Sentinel Lymph Nodes Affect Clinical Outcomes in Breast Cancer Patients Treated with Accelerated Partial Breast Irradiation
title_fullStr	Does the Presence of Cytokeratin Positive Individual Tumor Cells (N0(I+)) in Sentinel Lymph Nodes Affect Clinical Outcomes in Breast Cancer Patients Treated with Accelerated Partial Breast Irradiation
title_full_unstemmed	Does the Presence of Cytokeratin Positive Individual Tumor Cells (N0(I+)) in Sentinel Lymph Nodes Affect Clinical Outcomes in Breast Cancer Patients Treated with Accelerated Partial Breast Irradiation
title_sort	does the presence of cytokeratin positive individual tumor cells (n0(i+)) in sentinel lymph nodes affect clinical outcomes in breast cancer patients treated with accelerated partial breast irradiation
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/289394328a2846559a0bb8f9193e9fa5
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Does the Presence of Cytokeratin Positive Individual Tumor Cells (N0(I+)) in Sentinel Lymph Nodes Affect Clinical Outcomes in Breast Cancer Patients Treated with Accelerated Partial Breast Irradiation

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