NLRP1 restricts butyrate producing commensals to exacerbate inflammatory bowel disease

The inflammasome is normally activated by pathogens to induce tissue inflammation. Here the authors show that, in mouse experimental colitis models, Nlrp1 inflammasome sensor activates IL-18 to reduce beneficial colonic Clostridiales species, thereby decreasing microbial butyrate and its protective...

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Autores principales:	Hazel Tye, Chien-Hsiung Yu, Lisa A. Simms, Marcel R. de Zoete, Man Lyang Kim, Martha Zakrzewski, Jocelyn S. Penington, Cassandra R. Harapas, Fernando Souza-Fonseca-Guimaraes, Leesa F. Wockner, Adele Preaudet, Lisa A. Mielke, Stephen A. Wilcox, Yasunori Ogura, Sinead C. Corr, Komal Kanojia, Konstantinos A. Kouremenos, David P. De Souza, Malcolm J. McConville, Richard A. Flavell, Motti Gerlic, Benjamin T. Kile, Anthony T. Papenfuss, Tracy L. Putoczki, Graham L. Radford-Smith, Seth L. Masters
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/289da6d10257442191a1c6fe56d983a8
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spelling	oai:doaj.org-article:289da6d10257442191a1c6fe56d983a82021-12-02T17:32:45ZNLRP1 restricts butyrate producing commensals to exacerbate inflammatory bowel disease10.1038/s41467-018-06125-02041-1723https://doaj.org/article/289da6d10257442191a1c6fe56d983a82018-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06125-0https://doaj.org/toc/2041-1723The inflammasome is normally activated by pathogens to induce tissue inflammation. Here the authors show that, in mouse experimental colitis models, Nlrp1 inflammasome sensor activates IL-18 to reduce beneficial colonic Clostridiales species, thereby decreasing microbial butyrate and its protective effects on colitis.Hazel TyeChien-Hsiung YuLisa A. SimmsMarcel R. de ZoeteMan Lyang KimMartha ZakrzewskiJocelyn S. PeningtonCassandra R. HarapasFernando Souza-Fonseca-GuimaraesLeesa F. WocknerAdele PreaudetLisa A. MielkeStephen A. WilcoxYasunori OguraSinead C. CorrKomal KanojiaKonstantinos A. KouremenosDavid P. De SouzaMalcolm J. McConvilleRichard A. FlavellMotti GerlicBenjamin T. KileAnthony T. PapenfussTracy L. PutoczkiGraham L. Radford-SmithSeth L. MastersNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Hazel Tye Chien-Hsiung Yu Lisa A. Simms Marcel R. de Zoete Man Lyang Kim Martha Zakrzewski Jocelyn S. Penington Cassandra R. Harapas Fernando Souza-Fonseca-Guimaraes Leesa F. Wockner Adele Preaudet Lisa A. Mielke Stephen A. Wilcox Yasunori Ogura Sinead C. Corr Komal Kanojia Konstantinos A. Kouremenos David P. De Souza Malcolm J. McConville Richard A. Flavell Motti Gerlic Benjamin T. Kile Anthony T. Papenfuss Tracy L. Putoczki Graham L. Radford-Smith Seth L. Masters NLRP1 restricts butyrate producing commensals to exacerbate inflammatory bowel disease
description	The inflammasome is normally activated by pathogens to induce tissue inflammation. Here the authors show that, in mouse experimental colitis models, Nlrp1 inflammasome sensor activates IL-18 to reduce beneficial colonic Clostridiales species, thereby decreasing microbial butyrate and its protective effects on colitis.
format	article
author	Hazel Tye Chien-Hsiung Yu Lisa A. Simms Marcel R. de Zoete Man Lyang Kim Martha Zakrzewski Jocelyn S. Penington Cassandra R. Harapas Fernando Souza-Fonseca-Guimaraes Leesa F. Wockner Adele Preaudet Lisa A. Mielke Stephen A. Wilcox Yasunori Ogura Sinead C. Corr Komal Kanojia Konstantinos A. Kouremenos David P. De Souza Malcolm J. McConville Richard A. Flavell Motti Gerlic Benjamin T. Kile Anthony T. Papenfuss Tracy L. Putoczki Graham L. Radford-Smith Seth L. Masters
author_facet	Hazel Tye Chien-Hsiung Yu Lisa A. Simms Marcel R. de Zoete Man Lyang Kim Martha Zakrzewski Jocelyn S. Penington Cassandra R. Harapas Fernando Souza-Fonseca-Guimaraes Leesa F. Wockner Adele Preaudet Lisa A. Mielke Stephen A. Wilcox Yasunori Ogura Sinead C. Corr Komal Kanojia Konstantinos A. Kouremenos David P. De Souza Malcolm J. McConville Richard A. Flavell Motti Gerlic Benjamin T. Kile Anthony T. Papenfuss Tracy L. Putoczki Graham L. Radford-Smith Seth L. Masters
author_sort	Hazel Tye
title	NLRP1 restricts butyrate producing commensals to exacerbate inflammatory bowel disease
title_short	NLRP1 restricts butyrate producing commensals to exacerbate inflammatory bowel disease
title_full	NLRP1 restricts butyrate producing commensals to exacerbate inflammatory bowel disease
title_fullStr	NLRP1 restricts butyrate producing commensals to exacerbate inflammatory bowel disease
title_full_unstemmed	NLRP1 restricts butyrate producing commensals to exacerbate inflammatory bowel disease
title_sort	nlrp1 restricts butyrate producing commensals to exacerbate inflammatory bowel disease
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/289da6d10257442191a1c6fe56d983a8
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NLRP1 restricts butyrate producing commensals to exacerbate inflammatory bowel disease

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