Polyglutamine expansion affects huntingtin conformation in multiple Huntington’s disease models

Polyglutamine expansion affects huntingtin conformation in multiple Huntington’s disease models

Abstract Conformational changes in disease-associated or mutant proteins represent a key pathological aspect of Huntington’s disease (HD) and other protein misfolding diseases. Using immunoassays and biophysical approaches, we and others have recently reported that polyglutamine expansion in purifie...

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Main Authors: Manuel Daldin, Valentina Fodale, Cristina Cariulo, Lucia Azzollini, Margherita Verani, Paola Martufi, Maria Carolina Spiezia, Sean M. Deguire, Marta Cherubini, Douglas Macdonald, Andreas Weiss, Alberto Bresciani, Jean-Paul Gerard Vonsattel, Lara Petricca, J. Lawrence Marsh, Silvia Gines, Iolanda Santimone, Massimo Marano, Hilal A. Lashuel, Ferdinando Squitieri, Andrea Caricasole
Format: article
Language:EN
Published: Nature Portfolio 2017
Subjects:
Medicine
R
Science
Q
Online Access:https://doaj.org/article/28a4ca589dda4cb5b33f36313fe3c9c6
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https://doaj.org/article/28a4ca589dda4cb5b33f36313fe3c9c6

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